NIH-funded Postdoctoral Position

An NIH-funded postdoctoral position with a competitive salary is available at the Department of Genetics and Genomics, Boston Children’s Hospital. We are a dynamic team of molecular biologists, cardiovascular genetics, and bioinformaticians. Conducting cutting-edge research utilizing single-cell genomics and transcriptomics approach. We develop interdisciplinary methods including experimental techniques and technology development around single cell from the heart, as well as computational and statistical genetics/genomics methods. The ideal candidate should be highly motivated with research interests in genetics and cardiovascular disease. Candidates should be highly motivated, hold a recent Ph.D. in cell biology, molecular biology, genetics or related area of study. S/he should be relatively independent and able to generate and propose feasible hypotheses. S/he should have mastered the most advanced techniques and methodology in cell and molecular biology. S/he has excellent composition and writing skills for scientific papers. The postdoc fellow should be able to communicate and collaborate effectively with other lab staff, including technicians, students, and other research fellows. 

To apply, please send an email describing your current research activities and future research interests, a CV, and names and contact information for three references to Dr. Sangita Choudhury at sangita.choudhury@childrens.harvard.edu.

Postdoctoral Fellow

A postdoctoral fellow position is open for a highly creative and motivated applicant who has an interest in redox cell biology and physiology in the Thiagarajah Lab (http://thiagarajahlab.com) at Boston Children’s Hospital and Harvard Medical School. Experience in fluorescence imaging or transport physiology or membrane biophysics are highly desirable for this position. Research in the lab aims to understand how cells sense and interact with their surroundings and how membrane channels and transporters contribute to innate immune function, host-microbial symbiosis, and cellular metabolism. Projects in the lab use a variety of approaches and span several aspects of physiology, including both basic science and translational research connected to pediatric diseases. In particular, this position will involve investigating the basic mechanisms by which hydrogen peroxide at cellular membranes regulates downstream cellular processes. The research will use state-of-the art imaging in cell model systems as well as 3D cultures and tissue. The applicant will also support other lab experiments in our group and will be expected to undertake projects with minimal supervision.

Required Qualifications: 

·      The candidate must have a Ph.D. in a basic science. Experience in biological imaging and cell and molecular biology are highly desirable. 

·      Experience in cell culture, and animal handling are also desirable.

·      Candidates should also have a track record of productive research and publications, as well as excellent written and verbal communication skills.

·      The candidate must be able to work independently as well as collaboratively with other lab members.

Required Application Materials: 

Please send directly to: jay.thiagarajah@childrens.harvard.edu 

·      CV

·      Cover letter, including a brief statement of research interests and career goals and interest in the lab. 

·      Contact information for three references
 

Research Fellow Opportunity In Computational Genomics and Genetics

Division of Nephrology Boston Children’s Hospital Full-time postdoctoral research fellow positions are available in Dongwon Lee’s Laboratory. We study disease-associated genetic variants using computational approaches with a specific focus on transcriptional regulatory mechanisms. We have developed several machine-learning methods for the analysis of regulatory elements and regulatory variants (Lee et al., Nature Genetics 2015; Lee, Bioinformatics 2016; Lee et al., Genome Research 2018; Han et al., PNAS 2022). Our laboratory will continue to develop computational methods to model regulatory control of human diseases by incorporating improved machine-learning algorithms and single-cell multi-omic data (genomic, transcriptomic, and epigenomic.) New computational frameworks will help discover the molecular mechanisms driving the development and progression of human diseases.

To learn more, please visit our laboratory website at https://www.childrenshospital.org/dongwon-lee-lab.

Requirements: 1. The ideal applicant should have received a Ph.D. degree within 12 months or expect to do so within the following 12 months in computational biology, bioinformatics, bioengineering, biostatistics, computer science, or other related fields. 2. Strong programming skills in Python, C/C++, R, or equivalent are required. 3. Experience with Unix/Linux and working with large genetic and genomic data in a cluster-computing environment is highly preferred. 4. Excellent written and verbal communication skills and a willingness to write grant proposals and manuscripts are necessary.

Interested candidates should send a CV and a cover letter to: dongwon.lee@childrens.harvard.edu Dongwon Lee, PhD Assistant Professor of Pediatrics, Harvard Medical School Division of Nephrology, Boston Children’s Hospital Endowed Scholar, The Manton Center for Orphan Disease Research

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.

Post-doctoral training position

Investigate disease mechanisms caused by disruption of a postnatal alternative splicing regulatory network

The Tom Cooper lab at Baylor College of Medicine has open projects that investigate that investigate two related areas:  (1) the mechanisms and physiological consequences of conserved alternative splicing transitions regulated during mammalian postnatal development and (2) the disruption of this regulatory network that is the pathogenic mechanism of the microsatellite expansion disease myotonic dystrophy type 1 (DM1) that affects multiple tissues and is the most common cause of muscular dystrophy in adults. In DM1, the RNA expressed from the expanded allele disrupts regulation of a network of alternative splicing transitions that normally drive fetal to adult protein isoform expression. Expression of fetal protein isoforms unable to perform the functions required in adult tissue causes disease features. The investigations in these two areas are complementary and provide the basis for an exchange of ideas and collaboration within the lab.

We use our published and unpublished DM1 mouse models in heart, skeletal muscle, the gastrointestinal system and brain (newly initiated) as well as cell culture models for investigations of disease mechanisms. We also test therapeutic approaches including small molecules, CRISPR and antisense oligonucleotides in our lab and in collaborations with biotech companies. Representative papers:  PNAS 105, 2646; J Clin Invest 119, 3797; PNAS 110, 13570; Cell Reports 6, 336, PNAS 109, 4221, ACS Chem Biol 12, 2503; Human Mol Genet 27, 2789; J Am Heart Assoc 7, e010393., J Clin Invest Insight 6:e143465; Nucleic Acids Res 2023 10.1093/nar/gkac1219.

The study of DM1 pathogenic mechanisms identified a network of hundreds of postnatal alternative splicing transitions that occur shortly after birth, a large number of which are required for normal function. We investigate how the splicing networks are regulated and the physiological functions of selected conserved splicing transitions, particularly those disrupted in DM1. Representative papers:  PNAS 105, 20333; Genes Dev 24, 653; Nature Commun 5, 3603; Molecular Cell, 55, 592; eLife 6:e27192, Cell Reports 24, 197.

As the PI, my role is to work with each trainee to become an independent scientists and to help them reach the next step in their chosen career. I’ve mentored 40 trainees (24 pre-doc and 16 post-doc) who have gone on to a diverse range of successful independent careers in science. The success of our lab depends on our trainees and demonstrates the mutual benefits of active mentoring. See, “Previous Lab Members” on lab website for publications, grants and positions for all previous trainees.

Baylor College of Medicine is located within the Texas Medical Center (https://www.tmc.edu/), the largest medical center in the world known for its collaborative environment among basic and clinical scientists in a variety of fields and a growing biotech community (https://www.tmc.edu/innovation/innovation-programs/).

Houston is the fourth largest and most diverse city in the United States with all the amenities one would expect of a large city while being quite affordable (https://www.bcm.edu/about-us/life-in-houston).

Information about projects, lab environment, training goals, mentoring style and trainee outcomes can be found on our lab website https://www.bcm.edu/research/faculty-labs/tom-cooper-lab. Contact Dr. Tom Cooper to set up a time for a discussion at tcooper@bcm.edu; (713)-798-3141. Also feel free to contact individuals in the lab (contact info on lab website).

Senior Scientist

Location: Boston Children’s Hospital Harvard Medical School Boston, MA

Job Description: We seek a highly motivated and organized individual to help lead our efforts to investigate the molecular basis of blood and immune cell production and its disruption in disease. We are seeking a scientist with a Ph.D. or equivalent degree, with relevant research experience in hematology and/or immunology. The ideal individual will conduct their own research projects integrating results from human genetic studies with functional analyses of human hematopoiesis. This individual will also help oversee our laboratory, provide guidance to trainees and staff members, help lead and provide managerial oversight for laboratory projects, be involved in conceiving new scientific directions/ projects with the principal investigator, and help in writing and organizing grants.

This is an ideal position for someone interested in leading projects and conducting research in an independent manner, without excessive administrative responsibilities. We envision this being a long-term position in our laboratory with the possibility of promotion to associate director of the laboratory. This individual will help to promote the culture of our laboratory as an intellectually engaging, rigorous, productive, and positive workplace. They will be provided with many opportunities to develop projects, author manuscripts, participate in collaborations, and develop an international reputation in this field.

Representative Publications:

Zhao J, Jia Y, Mahmut D, Deik AA, Jeanfavre S, Clish CB, Sankaran VG. Human hematopoietic stem cell vulnerability to ferroptosis. Cell. 2023 Feb 16;186(4):732-747.e16. doi: 10.1016/j.cell.2023.01.020. PMID: 36803603.

Voit RA, Tao L, Yu F, Cato LD, Cohen B, Fleming TJ, Antoszewski M, Liao X, Fiorini C, Nandakumar SK, Wahlster L, Teichert K, Regev A, Sankaran VG. A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia. Nat Immunol. 2023 Jan;24(1):69-83. doi: 10.1038/s41590-022-01370-4. Epub 2022 Dec 15. PMID: 36522544; PMCID: PMC9810535.

Yu F, Cato LD, Weng C, Liggett LA, Jeon S, Xu K, Chiang CWK, Wiemels JL, Weissman JS, de Smith AJ, Sankaran VG. Variant to function mapping at single-cell resolution through network propagation. Nat Biotechnol. 2022 Nov;40(11):1644-1653. doi: 10.1038/s41587-022-01341-y. Epub 2022 Jun 6. PMID: 35668323; PMCID: PMC9646486.

Lareau CA, Ludwig LS, Muus C, Gohil SH, Zhao T, Chiang Z, Pelka K, Verboon JM, Luo W, Christian E, Rosebrock D, Getz G, Boland GM, Chen F, Buenrostro JD, Hacohen N, Wu CJ, Aryee MJ, Regev A, Sankaran VG. Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling. Nat Biotechnol. 2021;39: 451–461. PMID: 32788668 PMCID: PMC7878580

Ludwig LS, Lareau CA, Ulirsch JC, Christian E, Muus C, Li LH, Pelka K, Ge W, Oren Y, Brack A, Law T, Rodman C, Chen JH, Boland GM, Hacohen N, Rozenblatt-Rosen O, Aryee MJ, Buenrostro JD, Regev A, Sankaran VG. Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single- Cell Genomics. Cell. 2019 Mar 7;176(6):1325- 1339.e22. PubMed PMID: 30827679; PubMed Central PMCID: PMC6408267.

Please send inquiries and CV to principal investigator. The employer is prepared to sponsor a work-related visa for the ideal candidate. Application Method: Please apply by email to laboratory principal investigator: Vijay G. Sankaran, M.D., Ph.D. sankaran@broadinstitute.org

Postdoctoral Position in Immunology:

The Postdoctoral Scholar will work closely with Dr. Bernard Arulanandam (Professor of Immunology, Vice Provost for Research) and his research team to develop novel immunotherapeutics against human bacterial pathogens including Chlamydia and Acinetobacter. 

For more information please see the link below:

https://viceprovost.tufts.edu/announcements/postdoctoral-scholar-department-immunology

Postdoctoral Research Fellow

Postdoctoral Research Fellows – Immunology/Vaccinology Adjuvant Discovery and Development Laboratory, Precision Vaccine Program, Boston Children’s Hospital Boston Children’s Hospital, 300 Longwood Avenue, Boston, MA, 02115

There are two postdoctoral research fellowships available in Dr. David Dowling’s laboratory within the Precision Vaccines Program (PVP) of Boston Children’s Hospital and Harvard Medical School.

The PVP is a multidisciplinary research initiative founded in 2016 by its Director, Dr. Ofer Levy. The PVP has successfully secured multiple, large grants from the NIH/NIAID. Within the Dowling Laboratory, our overarching goals are to unravel the molecular mechanisms that underlie distinct immune responses of vulnerable human populations (e.g., the young, elderly, metabolic disorders or immunocompromised) and apply our discoveries to adjuvant and vaccine innovation, discovery, and development.

Our approach combines age- and species-specific screens with a focus on functional, biochemical, and systems immunology readouts in relevant in vitro and in vivo model systems. Furthermore, our scope also includes translating our research towards Phase I human clinical trials of novel and investigational vaccines. The Postdoctoral Research Fellows will lead projects related to adjuvant discovery development, in vitro and in vivo modeling, overseeing adjuvant medicinal chemistry, formulation, and novel delivery systems of vaccines. Approaches have an option to expand into use of systems vaccinology, in vivo modeling utilizing non-human primates, overseeing vaccine formulation toxicology, IND-enabling activities and contributing to Phase I clinical trials.

These positions are largely funded by NIH/NIAID grants and contracts, philanthropic funding and supplemented by sponsored agreements with pharmaceutical companies.

Qualifications:

• You must hold (or be near completion of) a degree at the doctoral-level (PhD and/or MD), and have a strong track record of productivity, or domain expertise, as evidenced by first-authored publications in peer-reviewed scientific journals/preprints or demonstrated contribution to ongoing projects.

• The ideal candidate(s) will have a track record of applying innovative experimental strategies to tackle important biologic problems, together with the communication and interpersonal skills required to make a positive contribution to a thriving intellectual environment.

• Experience of maintaining professional and collaborative communications with a focus on team science and some willingness to contribute to project management is a plus.

• Experience with using animal models, such as mice (primary), rat, pig, human primates is a plus, but not required.

• Experience of human in vitro modeling, such as Dendritic Cell, T-cell evaluation is a plus, but not required.

• Prior experience in studying distinct human populations that vary by age, sex, underlying disease, neuro-immune interphase, substance use disorders, or other demographic features is preferred.

• Review of applications will begin immediately. Applications will be considered on a rolling basis.

• Full-time position with competitive salary/benefits commensurate with experience. The position(s) is/are fully funded and may be held for up to 5 years.

• To apply, please email Drs. David Dowling (david.dowling@childrens.harvard.edu), with cc to Mr. Ahsan Saeed (Ahsan.Saeed@childrens.harvard.edu) with the following documents:

I. An updated curriculum vitae (CV) listing the names, title, and contact information for at least (2) references;

II. A brief statement or cover letter explaining research interests, motivation, and experience;

III. A publication/manuscript/pre-print the candidate has written.

Learn More About Us: • PVP Website: bit.ly/PrecVaccines • Twitter: @PrecVaccines • Twitter: @ @David_J_Dowling

Postdoctoral position

Full-time postdoctoral research fellow positions are available in Dongwon Lee’s Laboratory.

We study disease-associated genetic variants using computational approaches with a specific focus on transcriptional regulatory mechanisms. We have developed several machine-learning methods for the analysis of regulatory elements and regulatory variants (Lee et al., Nature Genetics 2015; Lee, Bioinformatics 2016; Lee et al., Genome Research 2018; Han et al., PNAS 2022).

Our laboratory will continue to develop computational methods to model regulatory control of human diseases by incorporating improved machine-learning algorithms and single-cell multi-omic data (genomic, transcriptomic, and epigenomic.) New computational frameworks will help discover the molecular mechanisms driving the development and progression of human diseases.

To learn more, please visit our laboratory website at https://www.childrenshospital.org/dongwon-lee-lab.

Requirements:

1. The ideal applicant should have received a Ph.D. degree within 12 months or expect to do so within the following 12 months in computational biology, bioinformatics, bioengineering, biostatistics, computer science, or other related fields.

2. Strong programming skills in Python, C/C++, R, or equivalent are required.

3. Experience with Unix/Linux and working with large genetic and genomic data in a cluster-computing environment is highly preferred.

4. Excellent written and verbal communication skills and a willingness to write grant proposals and manuscripts are necessary.

Interested candidates should send a CV and a cover letter to: dongwon.lee@childrens.harvard.edu

Dongwon Lee, PhD Assistant Professor of Pediatrics, Harvard Medical School Division of Nephrology, Boston Children’s Hospital Endowed Scholar, The Manton Center for Orphan Disease Research

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.

Postdoctoral Position

A Research Associate (Postdoctoral) position in Exocrine Gland Physiology Research is available immediately in the Dry Mouth and Dry Eye Research Laboratory at Tufts University School of Dental Medicine, Boston, MA. Applicants with Ph.D. and/or M.D. degrees are sought to investigate the impact of chronic inflammation on lacrimal and salivary gland myoepithelial cells functions that lead to symptoms of dry mouth and dry eye. A variety of cellular and molecular techniques are employed to perform these studies.

The preferred applicant must demonstrate experience with in vivo experimentation, the ability to perform immunostaining, PCR, western blotting, and tissue culture and must demonstrate excellent written and oral communication skills. The applicant must be able to independently plan and execute research activities including data collection, evaluation and analyses. Salary and benefits will be commensurate with experience and in accordance with NIH guidelines.

Candidates should send curriculum vitae to: Dr. Driss Zoukhri, Tufts University School of Dental Medicine, 1 Kneeland Street, DHS 639, Boston, MA 02111. Email: driss.zoukhri@tufts.edu

Tufts University is an equal opportunity employer committed to excellence and diversity. All qualified candidates, including women and minority candidates, are encouraged to apply.

Postdoctoral Associate, Program Evaluation and Research Development

Research Development at Boston University invites applicants for a postdoctoral associate focused on program evaluation and research development. The postdoc will gain training in the design, implementation, evaluation, and management of primarily training and workforce development programs involving graduate students, postdoctoral scholars, and faculty (e.g. Boston University’s Ignition Award program). However, the postdoc will also participate in the development and evaluation process for future programs that would benefit from a clear program evaluation approach.

This position is a three year postdoc position focused on program evaluation and development. In the first two years, the position will support program evaluation of existing training and workforce development programs at Boston University. The postdoctoral associate will design and implement evaluation plans and facilitate use of data toward improved outcomes and impact.  This will include developing and implementing evaluation methods based on existing program goals and metrics, analyzing qualitative and quantitative data, and developing data dashboards and publications that describe each program’s impacts. In the last year, the position will shift towards conceptualizing novel workforce development programs in collaboration with our team, and may include collaborating with staff and faculty to develop applications for grant funding opportunities.Required Skills

The postdoc’s primary responsibilities will be to:

• Use a mixed methods evaluation approach to evaluate key strategic workforce and training programs at Boston University. This will involve both developing protocols that are shared across several programs as well as instruments or methods tailored to evaluate specific program goals and outcomes; (40%)
• Analyze program outcomes data and develop data dashboards that will: inform Research Leadership and program faculty; enhance scholarly publications; and inform federal funding annual reporting requirements; (25%)
• Publish scholarly work in peer-reviewed journals in collaboration with Research team members (25%)
• Collaborate with Research Leadership to develop new workforce development programs, including program design, implementation, and evaluation. Collaboratively identify and develop applications for indpeendent funding to support new programs. (10%)

These activities will provide valuable experience for the Postdoctoral Associate in program design and management, and program evaluation and research. This training position is ideal for those interested in careers within academic administration, workforce development, or at university research centers with dedicated workforce components. The successful candidate will report to the Assistant Vice President and Assistant Provost of Research Development and PhD & Postdoctoral Affairs, and work closely with our Director of Technology Development and our Associate Vice President of Industry Engagement. 

This is a full-time, benefits-eligible appointment for three years with an anticipated start date in January 2023. To apply, please send a resume or CV and cover letter describing your background, qualifications, future goals, and why you believe you would be a strong fit for the position to sch1@bu.edu. Please be prepared to provide three references. Application materials will be considered on a rolling basis, but for full consideration, all materials must be received by November 1, 2022.

Applicants should have completed a PhD in education or a related social sciences discipline before starting the position, and have a strong interest in academic administration, workforce development, and/or program evaluation and research. The ideal candidate will have experience with qualitative and quantitative research methodologies and/or program evaluation. The candidate should have significant research-based experience and expertise in manipulating and analyzing large data sets with quantitative and text data, knowledge of survey design tools such as Qualtrics, NVivo (or other qualitative software), and/or SPSS (or other statistical analysis software). Effective project management skills (e.g., time management, problem solving, adaptability, and organization). Knowledge and skills required are obtained through a doctoral degree in public policy, public administration, biostatistics, education or evaluation-based research, or related field.

The individual should be able to work proactively and independently and must be comfortable managing competing project activities, deadlines, and outcomes. They also must possess strong communication and collaboration skills, and be able to work effectively with University leaders and faculty program directors.

Please note all newly hired staff and faculty will need to be in compliance with Boston University’s COVID-19 Vaccination and Booster Requirement within 30 days of date of hire. You must upload your vaccine documentation or request a medical or religious exemption (instructions). For further information on the University’s response to COVID-19, please visit the COVID-19 Resources site.

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, national origin, physical or mental disability, sexual orientation, gender identity, genetic information, military service, pregnancy or pregnancy-related condition, or because of marital, parental, or veteran status. We are a VEVRAA Federal Contractor.Job LocationBoston, United StatesPosition TypeFull-Time/RegularSalary GradeBased on experience

Apply here: https://bu.silkroad.com/epostings/index.cfm?fuseaction=app.jobinfo&jobid=310992&source=ONLINE&JobOwner=1016383&company_id=15509&version=1&byBusinessUnit=NULL&bycountry=0&bystate=0&byRegion=&bylocation=NULL&keywords=postdoctoral&byCat=&proximityCountry=&postalCode=&radiusDistance=&isKilometers=&tosearch=yes&city=

RNA Processing Lectures

The Tufts School of Graduate Biomedical Sciences is seeking a post-doc who can give a set of 3-4 lectures on RNA processing to early-stage Ph.D. students at Tufts University School of Medicine for this coming spring semester.

Other duties will include writing and grading an exam question on your lecture material and leading a paper-based discussion section.

There would also be the opportunity to help grade final research proposal papers.

The class is Biochemistry 230 and runs Mon and Wed from 9-11.

This is a wonderful way to get some teaching experience without being in charge of a full course.  Notes and slides from last year’s lectures will be available to help you prepare. A stipend will be provided.

For more information, please contact Prof. Amy S. Yee (amy.yee@tufts.edu); 617-636-6850.

Adjunct Lecturer(s) in Biotechnology and/or Evolution

Fisher College
Boston, MA
Type: Adjunct/Part-Time
Category: Biology

Job Description:

The fast-growing, innovative Biology Program at Fisher College is looking for adjunct faculty to teach SC225 Introduction to Biotechnology and/or SC402 Evolutionary Biology for the Spring 2023 semester. These courses are scheduled to run Mondays and Fridays, 2:00 PM – 3:15 PM, and Mondays and Wednesdays, 3:30 PM – 4:45 PM, respectively. Class starts on January 17th and ends on May 5th.

SC225 Introduction to Biotechnology (3 credits)

This course provides an introduction to the principles of biotechnology and its history. Molecular biotechnology techniques, including those required for recombinant DNA and gene cloning, and recombinant protein design and analysis, are emphasized and covered extensively. These techniques will be studied within the context of appropriate uses, limitations, and experiments that utilize specific techniques. The applications and ethical considerations of biotechnology are also covered including medical, microbial, plant, and forensic biotechnology applications. This course will provide real-world context and application-based learning for scientific principles, as well as highlight potential biotechnology-related career options in the biotechnological field.

SC402 Evolutionary Biology (3 credits)

This course provides an extensive and in-depth study of the history of evolutionary theory, evolutionary principles, and the application of evolutionary concepts to the field of biology and society. Geological, Paleontological, and historical breakthrough principles by Darwin are explored. Evolution is then explored on an individual basis, including the study of how traits are tracked and quantified and have evolved, quantified, and how they occur on a molecular basis to produce phenotypes. Key evolutionary concepts are covered, including: Drift, Selection, and Adaptation. Finally, the relevance of evolutionary concepts to society is studied, in the context of individual and societal behaviors, species, human evolution, and medicine that applies to evolutionary concepts.

Qualification:

The successful candidate will have the following:

• a Master’s degree or ABD (Ph.D. preferred) in biological sciences or related fields, including biotechnology, biophysics, and biomedical engineering.
• a record of successfully teaching undergraduate students.
• a demonstrated ability to work effectively with diverse students and foster an inclusive learning environment.
• the ability to work and communicate effectively with diverse community members, including students, professional staff, and faculty from a broad range of academic, socioeconomic, cultural, race, physical ability, age, neurodiversity, sexual orientation, gender identity, and other backgrounds.
• an inclusive pedagogy in all delivery methods.

Responsibility:

The successful candidate will be responsible for:

• preparing a syllabus for the course and distributing the approved syllabus to the students.
• teaching lecture courses.
• preparing quizzes and exams.
• grading assignments and exams in a timely manner.

How to Apply:

Interested applicants should email a CV and cover letter to Seung-Hwan Kim, Ph.D., Assistant Professor, Biology Program Director (seung-hwan.kim@fisher.edu).

Fisher College:

At Fisher College (https://www.fisher.edu/), a private, not-for-profit institution located on Beacon Street in Boston’s Back Bay, we believe college should be more than just higher education—it should be a life-changing experience, an introduction to a much larger world of possibilities, knowledge, and expectations. Small class sizes, personalized attention, dedicated professors, and a world of experiences inside and outside the classroom make Fisher College the perfect place to earn your degree. Here, students can pursue their passion and follow their interests. Offerings include a wide variety of undergraduate and graduate degrees that allow students the opportunity to advance their knowledge in programs that prepare them for a lifetime of achievement.

Postdoctoral Fellowship Position: Stem Cell Program in Carla Kim Lab

The Kim Lab in the Stem Cell Program at Boston Children’s Hospital seeks a highly motivated postdoctoral research fellow, who will conduct research under the mentorship of Dr. Carla Kim, Professor of Genetics at Harvard Medical School, Harvard Stem Cell Institute Faculty Member, and Member of the Stem Cell Program at Boston Children’s Hospital.

The broad interest of the Kim Lab is to use stem cell biology to increase our understanding of how mechanisms governing normal lung biology are impacted in lung disease and lung cancer.

Our lab utilizes co-culture organoid systems that allow us to define how mouse and human lung epithelial progenitor cells are regulated by cell-cell communication. Multiple projects are aimed at using these systems to shed light on lung cancer, emphysema, COPD, idiopathic pulmonary fibrosis and other lung diseases. The position offers an exciting opportunity to work closely with scientists and medical professionals in the highly collaborative and stimulating environment of the Stem Cell Program at Boston Children’s Hospital located in the vibrant Longwood / Harvard Medical Area.

There are several projects in the Kim lab for postdoctoral research fellows, including but not limited to:

• Transplantation of lung organoids to repair damaged lungs. The Kim lab is exploring the transplantation of healthy lung organoids as a tool for understanding lung stem cell biology and as a possible means to future cell-based therapy in diseased lungs.
• Organoid models of early stage lung cancer. We are using lung organoids that carry tumorigenic mutations to model the early steps of lung adenocarcinoma and devise new strategies to impair the progression of small lesions to full malignant growth.

Recent Kim Lab publications:

Progenitor potential of lung epithelial organoid cells in a transplantation model.

Louie SM, Moye AL, Wong IG, Lu E, Shehaj A, Garcia-de-Alba C, Ararat E, Raby BA, Lu B, Paschini M, Bronson RT, Kim CF. Cell Rep. 2022 Apr 12;39(2):110662. doi: 10.1016/j.celrep.2022.110662.

Louie SM, Moye AL, Wong IG, Lu E, Shehaj A, Garcia-de-Alba C, Ararat E, Raby BA, Lu B, Paschini M, Bronson RT, Kim CF. Cell Rep. 2022 Apr 12;39(2):110662. doi: 10.1016/j.celrep.2022.110662.

Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells.

Dost AFM, Moye AL, Vedaie M, Tran LM, Fung E, Heinze D, Villacorta-Martin C, Huang J, Hekman R, Kwan JH, Blum BC, Louie SM, Rowbotham SP, Sainz de Aja J, Piper ME, Bhetariya PJ, Bronson RT, Emili A, Mostoslavsky G, Fishbein GA, Wallace WD, Krysan K, Dubinett SM, Yanagawa J, Kotton DN, Kim CF. Cell Stem Cell. 2020 Oct 1;27(4):663-678.e8. doi: 10.1016/j.stem.2020.07.022. Epub 2020 Sep 4.

BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency.

Gupta M, Concepcion CP, Fahey CG, Keshishian H, Bhutkar A, Brainson CF, Sanchez-Rivera FJ, Pessina P, Kim JY, Simoneau A, Paschini M, Beytagh MC, Stanclift CR, Schenone M, Mani DR, Li C, Oh A, Li F, Hu H, Karatza A, Bronson RT, Shaw AT, Hata AN, Wong KK, Zou L, Carr SA, Jacks T, Kim CF. Cancer Res. 2020 Sep 15;80(18):3841-3854. doi: 10.1158/0008-5472.CAN-20-1744. Epub 2020 Jul 20.

Requirements:

The candidate should have a Ph.D. or an M.D./Ph.D. No postdoctoral experience is required.

How to apply:

Interested applicants should email their CV, a cover letter indicating research experience, interests and goals, and names/contact information for at least three academic references to the Dr. Carla Kim at Carla.Kim@childrens.harvard.edu

Multiple Tenure-Track Faculty Positions at The BioFrontiers Institute, University of Colorado Boulder

The BioFrontiers Institute at the University of Colorado Boulder is pleased to announce a multi-position faculty hiring initiative. As an interdisciplinary research institute with global impact, we seek talented, ambitious individuals from diverse backgrounds with boundary-pushing vision in the life sciences, physical sciences, computational biology, or bioengineering. We are particularly interested in applicants whose work intersects with the institute themes of regenerative biology & engineering, degenerative diseases, infectious diseases, computational biology, or Down syndrome. Areas of interest include but are not limited to: stem cell biology and organoids, tissues and organs on a chip, biomaterials, tissue engineering, diagnostics and drug delivery, immunoengineering, multiscale and multimodal optical imaging, biomechanics, and platform development for translational medicine. We encourage creative and collaborative individuals, particularly women and people identifying with underrepresented minority groups, to apply.

The BioFrontiers Institute integrates faculty from 11 academic departments across 2 colleges to address significant problems in biology and medicine with interdisciplinary approaches. Successful candidates will have a tenure home in either the College of Engineering and Applied Science or in the College of Arts and Sciences. They will develop an independent, internationally recognized research program that is synergistic with other programs of the University of Colorado community. Duties will include research, teaching, and service. Candidates must have a Ph.D. and/or M.D. as well as a demonstrated commitment to teaching and fostering diversity through inclusive practices.

All applications received by November 1, 2022 will receive full consideration. Review will continue until December 1, 2022. The University of Colorado Boulder conducts background checks for all final applicants. As an Equal Opportunity/Affirmative Action employer, the University of Colorado is committed to diversity and equity in education and employment and is sensitive to the needs of dual-career couples.

Application materials will be accepted electronically through the CU Boulder Jobs Site (position #42958) starting in October 2022: https://jobs.colorado.edu/jobs/JobDetail/?jobId=42958

Postdoctoral Scholar

Department of Immunology
Tufts University, School of Medicine
Boston, Massachusetts

Department Overview

The Department of Immunology maintains research programs that focus on translational and basic research in areas relevant to human disease. Our goal is to become a world-class center for the study of inflammation and the targeted development of novel therapeutics for both treatment and prevention of immune-mediated diseases. The strength of the department lies with an integrated faculty interested in understanding how immunological, physiological and metabolic pathways interact to produce dysregulated, innate and adaptive host responses in a wide array of chronic diseases. These include autoimmunity, cardiovascular disease, transplantation, infectious diseases, and others.

Position Description

The Postdoctoral Scholar will work closely with Dr. Bernard Arulanandam (Professor of Immunology, Vice Provost for Research) and his research team to develop novel immunotherapeutics against human bacterial pathogens including Chlamydia and Acinetobacter.

Primary focus in Dr. Arulanandam’s research is to understand the immunopathogenesis of Chlamydia trachomatis, the leading cause of sexually transmitted bacterial disease worldwide.  The postdoc. will lead the development of an exciting novel human genital organoid chlamydial infection system to dissect host-pathogen interaction. The long-term research goal is to identify immune targets from this organoid infection system for further development of therapeutics to reduce chlamydial pathogenesis and enhance host protective immunity. This postdoc. candidate will also participate in the development of preventive vaccines and antibody-based treatment against Acinetobacter baumannii, an important multidrug-resistant pathogen of the general population and military personnel.

The successful candidate will be a highly motivated individual able to work efficiently and productively in a fast-paced, multifaceted research environment. Main responsibilities of the candidate include design and execution of research projects, presentation and publication of research results, identification of new grant opportunities and playing a major role in the writing and submission of grant applications.

The initial appointment will be for one year, with the possibility of extension for an additional 2, made on a year-by-year basis, dependent on funding.

Years of related experience: 1-3 years of experience

Required Education: Ph.D.

Required computer skills: working knowledge of Excel, Prism-GraphPad.

Other: Initiative, problem-solving skills, multi-tasking skills, time management skills, and excellent collegiality and collaborative skills are needed.

Preferred Qualifications:

The preferred candidate should have a doctorate in a field related to cell biology, immunology or microbiology. One to three years of postdoctoral experience is preferred. A record of published scientific research, advanced methodological skills, scientific writing, and scientific presentations are ideal. Successful experiences in grantsmanship and laboratory management is preferred.

Please send a letter of application, curriculum vitae, 2-3 publications, and the names and contact information of three references to: Angela Lu;  angela.lu@tufts.edu

Senior Staff Scientist

BOSTON CHILDREN’S HOSPITAL
HARVARD MEDICAL SCHOOL

We are seeking a full-time Senior Scientist with a core competence in Quantitative Clinical Pharmacology and Pharmacokinetics and experience in laboratory management. The successful candidate will conduct and supervise assay development and performance, and modeling of the acquired data. Our overarching goals are for the PK Laboratory Senior Staff Scientist to conduct and supervise assay development and performance, and modeling of the acquired data. Other important goals include enhancement of departmental research that could involve such data, by teaching, collaboration, and development of research projects. Candidates are highly encouraged to explore their own ideas, and present their work at conferences.

Responsibilities and Qualifications:

Laboratory:

• Ensures laboratory certification based on national standards.
• According to established protocols, good laboratory practices (GLPs) and assigned schedules, supervises and performs a variety of routine laboratory analyses and procedures, utilizing standard laboratory equipment including HPLC, LCMS.
• Maintains equipment and organizes the laboratory’s supplies; provides personnel training and guidance on experimental design and experimental approaches.
• Integrates systems and processes to ensure adequate operation of the laboratory, and safe, accurate and timely provision of pharmacokinetic and pharmacometric services.
• Establishes budgetary requirements for the provision of pharmacometrics and pharmacokinetics studies, including staffing requirements and technological needs.
• Supervises and bi-annually evaluates support staff in the laboratory.

Research:

• Participates in collaborative research to improve patient care and advance academic productivity.
• Integrates and enhances interactions between the basic sciences, clinical sciences and pharmacy practice in areas of research, education, and service.
• Translates novel technologies into clinical investigation and collaborates with other basic researchers or clinical investigators.
• Communicates teaching and research activities.
• Keeps abreast of the latest developments in the field; and identifies and utilizes emerging research technologies.
• Helps accomplish the long-term research goals of the laboratory, including assisting in the preparation of grant applications.

Pharmacy:

• Provides consultative pharmacokinetic/pharmacodynamics service in conjunction with the Department of Pharmacy at Boston Children’s Hospital. This will include patient specific as well as population-based queries. Additionally, this Senior Scientist will oversee the development and implementation of pharmaceutical analytic services for dosage form development, stability indicating assays and other biopharmaceutic analyses consistent with current USP standards.

Qualification:

• At least 5 years of experience and PharmD or Ph.D. in pharmacology.
• Postdoctoral experience and strong academic credentials in the discipline of pharmacology.
• Experience in analytical techniques using human, animal, and in vitro samples (e.g., HPLC, LC-MS, bioassays).
• Experience in pharmacokinetic modeling.

POSTDOCTORAL SCHOLAR

A postdoctoral position is available for an enthusiastic scientist to work in the area of regulatory T cell immunology. The position is located at the division of Immunology, Boston Children’s Hospital and Harvard Medical School under the supervision of Dr. Louis-Marie Charbonnier. This lab focuses on elucidating the mechanisms involved in the breakdown of immune tolerance in monogenic disorders of immunity, autoimmune diseases and allergic inflammatory disorders, with a
particular focus on the role of regulatory T cells in disease athogenesis. More specifically, the projects involve the regulatory circuitries underlying Treg cell fate decisions, Treg cell heterogeneity and reprogramming as well as metabolic and molecular therapeutics to promote immune tolerance, in the context of autoimmunity, Hyper IgE syndrome and Primary Immunodeficiencies.

Relevant articles :
1- Charbonnier LM, Wang S, Georgiev P, Sefik E and Chatila TA. Control of Peripheral Tolerance by Regulatory T CellIntrinsic Notch signaling. Nat. Immunol. 2015 Nov;16(11):1162-73
2- Charbonnier LM, Cui Y, Stephen-Victor E, Harb H, Lopez D, Bleesing JJ, Garcia-Lloret MI, Chen K, Ozen A, Carmeliet P,
Li MO, Pellegrini M, Chatila TA. Functional reprogramming of regulatory T cells in the absence of Foxp3. Nat Immunol. 2019
Sep;20(9):1208-1219
3- Zemmour D, Charbonnier LM, Leon J, Six E, Keles S, Delville M, Benamar M, Baris S, Zuber J, Chen K, Neven B, GarciaLloret MI, Ruemmele F, Brugnara C, Cerf-Bensussan N, Rieux-Laucat F, Cavazzana M, André I, Chatila TA, Mathis D, Benoist C.
Single cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations. Nat
Immunol. 2021 May;22(5):607-619.
4- Abdel-Gadir A, Stephen-Victor E, Gerber GK, Noval Rivas M, Wang S, Harb H, Wang L, Li N, Crestani E, Spielman S,
Secor W, Biehl H, DiBenedetto N, Dong X, Umetsu DT, Bry L, Rachid R, Chatila TA. Microbiota therapy acts via a regulatory T
cell MyD88/RORγt pathway to suppress food allergy. Nat Med 2019 Jul;25(7):1164-1174.

This position is ideal for an individual with high interest in high throughput methodologies (scRNA-seq, ChIP-seq, ATAC-seq) to
study basic and translational Treg cell immunoregulatory functions and development. Candidates are expected to be
independent and self-motivated with experience and/or knowledge of contemporary high-throughput sequencing techniques
as well as immunological mouse models, human blood sample processing as well as cell culture, flow cytometry and cell
sorting.Candidates must hold a doctoral degree (PhD, MD, or the equivalent) in molecular, cell biology, immunology or related
fields.

Those with experience in Primary Immunodeficiencies, mouse models of immunology, mammalian cell isolation, cell
culture, flow cytometry, in vitro gene manipulation, RNA isolation and handling, hands-on expertise in molecular biology and
transcription regulation are highly encouraged to apply. Performing high-throughput sequencing library preparation is highly
desirable. In addition, strong oral and written communication skills, excellent organizational and recordkeeping skills with high
attention to detail, the ability to work independently as well as collaboratively with others, personal and professional integrity
and flexibility in work scheduling are highly valued.

To apply, interested individuals should submit their CV, a cover letter outlining interests and accomplishments to Dr. LouisMarie Charbonnier : Louis-Marie.Charbonnier@childrens.harvard.edu
Salary will follow NIH guidelines commensurate with training and experience. Boston Children’s Hospital, Harvard Medical
School is an Affirmative Action/Equal Opportunity Employer