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Research Scientist – Stem Cell Modeling and Genome Editing

Description

The Collaborative Center for X-Linked Dystonia-Parkinsonism (CCXDP) is a global disease consortium based at Massachusetts General Hospital that is focused exclusively on a rare neurodegenerative disorder endemic to the Philippines. We are an international coalition of scientists, physicians, and industry partners throughout North America, Europe, and Asia all working together to solve X-Linked Dystonia-Parkinsonism (XDP), a severe movement disorder. The hub of our network is a group of core investigators at MGH with affiliations spanning Harvard Medical School, the Harvard Stem Cell Institute, and the Broad Institute.

CCXDP is seeking a Research Scientist to lead a broad range of studies applying genome editing technologies to interrogate DNA sequence variants linked to XDP and related movement disorders in induced pluripotent stem cell (iPSC) models. You will work closely with a dynamic team including senior investigators, junior faculty members, PhD-level staff scientists, research technicians, and students.

What you’ll do:

  • Perform studies of induced pluripotent stem cells using CRISPR-based genome editing methods to alter disease-related DNA sequence variants of interest.
  • Differentiate engineered iPSC lines towards neuronal and glial lineages using established protocols.
  • Characterize cellular phenotypes in engineered iPSCs using a range of molecular, biochemical, and/or imaging-based assays
  • Investigate, create, and develop new methods and technologies for research advancements.
  • Prepare written data reports, including methodology, figure preparations, written description of the study in the form of manuscripts and/or progress reports.
  • Contribute to research presentations at local, national, and international meetings.
  • Organize and/or draft material for the preparation of research papers, manuscripts, or other documents for publication and/or presentation.

Requirements

  • Msc (required) or PhD (preferred) in relevant biomedical discipline with 3-5 years of experience in a related research field.
  • Experience with mammalian tissue culture with an emphasis on iPSCs
  • Experience with CRISPR-based genome editing methods and related molecular genetic techniques.
  • Ability to work independently and as a team member.
  • Excellent organizational and communication skills
  • Ability to prioritize tasks, set deadlines, and adapt to shifting priorities in response to changing deadlines and needs of the lab.
  • Ability to function with speed, precision, and an understanding of theory behind protocols and experiments.

To apply visit: https://partners.taleo.net/careersection/ex/jobdetail.ftl?job=3209030&tz=GMT-04%3A00&tzname=America%2FNew_York

Computational postdoc position at Boston Children’s Hospital and Harvard Medical School

The Gutierrez-Arcelus Lab at Boston Children’s Hospital and Harvard Medical School (gutierrezarceluslab.com) is seeking a dry lab postdoctoral research fellow to work on systems immunology of immune mediated diseases. This is a fully funded position for at least two years. The postdoctoral fellow will be conducting research mainly in collaboration with Dr. Janet Chou’s lab to understand the role of obesity in multisystemic inflammatory syndrome in children (MIS-C). This will involve analyzing single cell and other functional genomics datasets, as well as genetic variation data.

The Gutierrez-Arcelus lab is an interdisciplinary group that utilizes genetics and multiomics quantitative approaches to deepen our understanding of human gene regulation,
how it varies between individuals, and how these regulatory differences contribute to immune-mediated disease. The lab is part of the Division of Immunology at Boston Children’s Hospital, and Harvard Medical School, and is affiliated with the Broad Institute. We have both dry and wet lab space, and we collaborate with immunology laboratories. The Boston area is a vibrant and dynamic scientific community that offers unique opportunities for scientific growth.

Successful candidates must hold (or soon receive) a Ph.D., M.D. or M.D/Ph.D. degree in the field of genomics, biostatistics, bioinformatics, or other quantitative sciences; and should have a track record of research achievements and ability to work independently and collaboratively in a team. Other desired (but not required) skills for this position are

a) transcriptomics or epigenomics background,

b) immunology background;

c) human genetics background.

Interested applicants should email mgutierr@broadinstitute.org with their CV.

Postdoctoral Research Fellow for the Alex Cuenca Lab at BCH

The Cuenca lab at Boston Children’s Hospital is seeking a highly motivated postdoctoral research fellow that is interested in innate immunity, allograft immunity, and therapeutics designed to delay allograft rejection/generate allograft tolerance. Our lab’s overall goal is to understand how to shape the transplant recipient’s bone marrow and innate immunity to provide allograft tolerance.

Preferred qualifications include:
1) Proficiency and knowledge of immunological assays (ie ELISA, Luminex, and Flow Cytometry)
2) Ability to work independently and as part of a team
3) Animal handling, breeding, and surgical skills
4) Basic statistical methods
5) 0-3 years of post-doctoral expertise
6) MD and/or PhD

Salary is competitive and commensurate with years of post-doctoral experience/qualifications

Please send CV, statement of interest, and 3 references to:
Alex Cuenca, MD PhD (alex.cuenca@childrens.harvard.edu)

Postdoctoral Researchers

Tufts University has openings for three post-doctoral researchers to engage in cross-cutting projects focusing on the development of “precision” models and algorithms with applications in learning science, nutrition, and medicine. These three domains are seeing an explosion in the types and quantities of information that can be collected to provide insight into various aspects of human physiology and psychology. Practitioners in these fields are eager to use these data to understand the dynamics of a wide variety of processes taking place both within and between people and make timely and accurate predictions at the scale of the individual. The characteristics of the data however render traditional analysis methods, largely concerned with population level statistics, inadequate. Many of these challenges arise from issues of heterogeneity. Some sources such as wearables provide data continuously. Others yield measurements at only a few discrete points in time (e.g., biomarkers derived from saliva samples) while audio and video are examples of data that may be provided in noncontiguous intervals of varying length. Most of these data are only indirectly related to the phenomena of interest with no explicit model linking the two as is the case for student work in the context of learning, electronic medical records for nutrition or medicine, or the results of questionnaires in all applications of interest. Finally, although the quantity of data collected about any one individual may be relatively large, practical considerations make the number of participants associated with most studies relatively small, on the order of tens at most making these simultaneously “big” and “small” data problems. 

While learning, nutrition, and medicine each possess unique characteristics, the common challenges just described strongly suggest that an integrated approach to “precision analytics” will provide a fruitful path forward. Thus, we are looking for three PhD-level scientists with interests in pioneering rigorous and at the same time useful solutions to the problems outlined above. Each researcher will lead the effort in a specific domain, and the group as a whole will work collaboratively to exploit underlying commonalities across the different disciplines. Successful candidates will have a PhD in a quantitative discipline such as applied mathematics, statistics, signal processing, machine learning, or physics with a track record of high-quality publications in relevant journals and peer reviewed conferences. We seek individuals who will advance the state of the art in machine learning, data science, artificial intelligence etc. in a manner that also support the research goals and interests of our application domain partners drawn from

  • The Tufts Center for Applied Brain and Cognitive Sciences
  • The Tufts Institute for Research on Learning and Instruction
  • Jean Mayer USDA Human Nutrition Research Center on Aging
  • The Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance

For more information about this position, please email Prof. Eric Miller at eric.miller@tufts.edu. 

Interested candidates should provide Prof. Miller with a copy of their CV, list of references, cover letter, and copies of relevant articles, theses, technical reports etc.

Instructor-Fixed Term

Biochemistry & Molecular Biology

Advertised: Apr 20, 2022 Eastern Daylight Time
Applications close: Apr 20, 2024 Eastern Daylight Time

Apply here: https://careers.msu.edu/en-us/job/510239/instructorfixed-term

This is a 12-month, fixed-term (non-tenure track) position with an expected start date in August 2022. The successful candidate will be an innovative and engaging educator who will implement the online instruction of our 200-level and 400-level comprehensive biochemistry courses for non-majors that are offered in the fall, spring, and summer semesters. These popular courses have large enrollments of MSU students who are health- and life-science related majors, chemical engineers, and also serve continuing education students from outside the university. The primary responsibility of the successful candidate will be to manage and maintain these two established online offerings. Specific duties include the delivery of current materials, including course lectures and learning activities, the development and administration of course exams, and evaluation of other student work. The successful candidate will also hold office hours, mentor students, and train and supervise course teaching assistants. We anticipate that, over time, the successful candidate will update the courses regularly by incorporating new scientific discoveries, taking advantage of emerging technologies in developing and presenting course material, and collaborating with other educators as the online courses evolve. We also highly encourage engagement in Discipline-Based Education Research and subject matter pedagogy. The College and Department are committed to building and supporting an equitable and inclusive community of faculty, staff, and students. The department is especially interested in receiving applications from candidates who have demonstrated a commitment to diversity and inclusion and who may bring perspectives from a nontraditional educational background and/or an understanding of the experiences of persons from underrepresented groups.

Equal Employment Opportunity Statement

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, citizenship, age, disability or protected veteran status.

Required Degree

Masters -Biochemistry, Molecular Biology, or closely related field

Desired Degree

Doctorate -Biochemistry, Molecular Biology, or closely related field

Minimum Requirements

Masters degree required. A doctorate is preferred in biochemistry, molecular biology or closely related field.

Experience in teaching science courses at the college or university level. Experience teaching diverse populations of students and/or evidence of commitment to professional development around diversity, equity, and inclusion topics.

Desired Qualifications

Proficiency in biochemistry and molecular biology. Demonstrated effective teaching skills such as experience in online teaching, which may include video production and delivery, familiarity with learning management systems like Brightspace D2L or other education technologies that support online learning, knowledge of accessibility standards and use of quality assurance tools such as Quality Matters or OLC Quality Scorecard, experience with teaching in large-enrollment course, experience in curriculum development, examples of collaboration during course instruction curriculum development or in other professional contexts, evidence of professional development, participation in or familiarity with scholarship of teaching and learning (SOTL) or discipline based educational research (DBER).

Required Application Materials

Applicants should submit the following documents to jobs.msu.edu (posting 773205):

  • cover letter
  • curriculum vitae
  • scientific writing sample (e.g., research manuscript, medical communication, technical report, science blog post, news article)
  • teaching portfolio (limited to 10 pages) describing past roles and responsibilities based on a brief narrative and supporting information such as syllabi, assessments, student evaluations, developed course curricula and course materials, including any involvement in online teaching. A representative short (5 to 10-minute) lecture video or other previously delivered online material is encouraged (if not providing public links for online material, please contact the Chair of Search Committee for alternative options).   
  • teaching philosophy (limited to 2 pages) with documentation of philosophy implementation and  contributions to Diversity, Equity, and Inclusion (DEI). Thoughts on the particular challenges and opportunities of online teaching are highly encouraged. 
  • contact information for 3 references in the cover letter

Together-we-will Statement

The university is requiring all MSU students, faculty and staff to be vaccinated against COVID-19 with limited exceptions. Learn more at: https://msu.edu/together-we-will/

Special Instructions

The applicant should also provide contact information for 3 references in the cover letter. Please direct questions regarding the position to Dr. Michael Feig, Chair of the Search Committee (feig@msu.edu).

Review of applications will begin on May 16 and continue until a suitable candidate is identified.

Review of Applications Begins On

05/16/2022

Website

https://bmb.natsci.msu.edu/

Department Statement

The missions of the Department of Biochemistry & Molecular Biology at Michigan State University are to discover and transfer new knowledge about the molecular basis of life through basic and cross-disciplinary biomolecular science research while maintaining a collegial and fertile learning environment. Additional information about the BMB Department, including descriptions of current courses, can be found at the BMB departmental website.  https://bmb.natsci.msu.edu/

MSU Statement

Michigan State University has been advancing the common good with uncommon will for more than 160 years. One of the top research universities in the world, MSU pushes the boundaries of discovery and forges enduring partnerships to solve the most pressing global challenges while providing life-changing opportunities to a diverse and inclusive academic community through more than 200 programs of study in 17 degree-granting colleges.

RESEARCH SCIENTIST I, METHODS DEVELOPMENT LAB, BROAD INSTITUTE

Apply Here: https://broadinstitute.wd1.myworkdayjobs.com/broad_institute/job/CambridgeMA/Research-Scientist-I_3690?shared_id=95f2b011-c7c7-45f6-bb89-9c239ad5c925

The combination of biotechnological and computational advances over the past decade has substantially augmented our ability to create high-performance methods, thereby driving biological discovery and development of transformative medical breakthroughs. While this accelerated pace of methods development offers great promise, the rapid expansion of novel techniques gives rise to new challenges regarding adoption and effective implementation. To capitalize on these exciting technological advances with a strong emphasis on driving novel methods adoption, the Broad Institute has formed the Methods Development Lab, a highly collaborative entity to identify high-value scientific frontiers and generate and disseminate high-performance end-to-end productionized approaches to the community.

The Research Scientist is responsible for driving the development of novel molecular techniques related to -omic technologies that will positively impact the Broad Institute science and technological capabilities and offerings within the Genomics Platform. The Research Scientist will lead collaborative projects with Broad Programs and Platforms, with an emphasis on Cell Circuits, the Klarman Cell Observatory, Gene Regulation Observatory, Immunology Program, Data Sciences Platform, and Genetic Perturbation Platform. In addition, the Research Scientist will keep current with the state of the field and interests/needs of Broad researchers and work with the Methods Development Lab Group Leader to conceptualize, prioritize, and then develop new methods. The Research Scientist will work closely with Genomics Platform R&D, Automation, LIMS, production teams, and Data Sciences Platform to translate novel methods into production scale processes to make them available to the community.

RESPONSIBILITIES

• Drive novel technology development projects within specific areas as agreed upon with the MDL Group Leader.

• Help evaluate new -omic technologies to determine utility, impact, fit with Genomics Platforms capabilities and interests.

• Work closely with DSP computational biologists to create analytic methods for novel technologies and novel resources for the community. • Mentor junior team members and serve as a resource for molecular biology techniques.

• Oversee research associates and computational biologists working on MDL projects.

• Assist in obtaining federal, philanthropic, institutional, or industrial funding opportunities for technology development.

• Publish novel methods in collaboration with Broad scientists.

• Seek intellectual property protection for inventions that are conceived of or developed while a member of the GP. SKILLS AND ABILITIES

• Must be passionate and deeply committed to the mission of the Methods Development Lab and the entire Broad.

• Must be forward-thinking and innovative, with a nimble scientific/technical mind, able to rapidly develop and execute on creative solutions.

• Excellent communicator in written and verbal form.

• Deep molecular biology experience.

• Strong data analysis skills.

QUALIFICATIONS

• PhD in Molecular Biology

• Proven experience in writing successful proposal for funding of technology development

Apply: https://broadinstitute.wd1.myworkdayjobs.com/broad_institute/job/Cambridge-MA/ResearchScientist-I_3690?shared_id=95f2b011-c7c7-45f6-bb89-9c239ad5c925

POSTDOCTORAL ASSOCIATE, VALLABH/MINIKEL LAB, BROAD INSTITUTE

The Vallabh/Minikel lab at the Broad Institute of MIT and Harvard seeks an independent Postdoctoral Associate motivated to impact human health by driving multiple projects of therapeutic and translational importance. This initiative is led by Dr. Sonia Vallabh and Dr. Eric Minikel, who became scientists in response to Sonia’s own genetic test report. The goal of our work is to discover, develop, characterize and advance effective treatments for prion disease, a rapidly fatal and currently incurable neurodegenerative disease.

You can read more about our mission here: http://www.vallabhminikel.org/

There are a number of projects in the lab for which an incoming postdoc could serve as champion. Many revolve around cell and tissue-based experiments aimed at illuminating drug mechanism of action and/or in vivo characterization of therapeutic activity in the rodent brain. Mechanistic studies will require the ability to generate and test new hypotheses using a range of in vitro and cell culture systems. In vivo experiments will require both deep pharmacological characterization of drug distribution and activity and proof-of-concept efficacy studies in disease models. The results should inform and enable the near-term development of human therapeutics for a currently untreatable disease.

The position will require several skill sets, many of which can be learned on the job, but the ideal candidate will come with experience in at least a few of the following areas: live animal handling and surgery; tissue harvest, preparation, dissection and staining; immunohistochemistry (IHC); tissue culture, immunofluorescence (IF), cloning, and transfection; quantifying RNA and protein (ddPCR, qPCR, ELISA, Western blots), production and characterization of recombinant protein.

A background in neuroscience, molecular biology and/or chemical biology will be extremely helpful.

The successful candidate will be able to take leadership of projects in a largely self-directed environment and will be ready to supervise a research assistant and to effectively manage relationships with vivarium staff, industry collaborators, contract research organizations, and other academic groups. A keen eye for statistical rigor is essential, and proficiency in data analysis is a plus.

REQUIREMENTS • A PhD in molecular biology, neurobiology, or an allied field. • Exquisite attention to detail and organizational capacity. • Enthusiasm for working as part of a team sharply focused on therapeutic outcomes and translation to human clinical trials. • We encourage candidates to apply as early as possible and will review applications on a rolling basis. Required application documents include a cover letter and CV. Please write a cover letter! Our lab is a unique environment, and we want to get a feel for why you are interested in working here in particular, out of all the labs out there. References will be requested on follow-up. We regret that we will not be able to reply to every applicant.

Contact: Sonia Vallabh at svallabh@broadinstitute.org

POSTDOCTORAL SCHOLAR

A postdoctoral position is available for an enthusiastic scientist to work in the area of regulatory T cell immunology. The position is located at the division of Immunology, Boston Children’s Hospital and Harvard Medical School under the supervision of Dr. Louis-Marie Charbonnier. This lab focuses on elucidating the mechanisms involved in the breakdown of immune tolerance in monogenic disorders of immunity, autoimmune diseases and allergic inflammatory disorders, with a
particular focus on the role of regulatory T cells in disease athogenesis. More specifically, the projects involve the regulatory circuitries underlying Treg cell fate decisions, Treg cell heterogeneity and reprogramming as well as metabolic and molecular therapeutics to promote immune tolerance, in the context of autoimmunity, Hyper IgE syndrome and Primary Immunodeficiencies.

Relevant articles :
1- Charbonnier LM, Wang S, Georgiev P, Sefik E and Chatila TA. Control of Peripheral Tolerance by Regulatory T CellIntrinsic Notch signaling. Nat. Immunol. 2015 Nov;16(11):1162-73
2- Charbonnier LM, Cui Y, Stephen-Victor E, Harb H, Lopez D, Bleesing JJ, Garcia-Lloret MI, Chen K, Ozen A, Carmeliet P,
Li MO, Pellegrini M, Chatila TA. Functional reprogramming of regulatory T cells in the absence of Foxp3. Nat Immunol. 2019
Sep;20(9):1208-1219
3- Zemmour D, Charbonnier LM, Leon J, Six E, Keles S, Delville M, Benamar M, Baris S, Zuber J, Chen K, Neven B, GarciaLloret MI, Ruemmele F, Brugnara C, Cerf-Bensussan N, Rieux-Laucat F, Cavazzana M, André I, Chatila TA, Mathis D, Benoist C.
Single cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations. Nat
Immunol. 2021 May;22(5):607-619.
4- Abdel-Gadir A, Stephen-Victor E, Gerber GK, Noval Rivas M, Wang S, Harb H, Wang L, Li N, Crestani E, Spielman S,
Secor W, Biehl H, DiBenedetto N, Dong X, Umetsu DT, Bry L, Rachid R, Chatila TA. Microbiota therapy acts via a regulatory T
cell MyD88/RORγt pathway to suppress food allergy. Nat Med 2019 Jul;25(7):1164-1174.

This position is ideal for an individual with high interest in high throughput methodologies (scRNA-seq, ChIP-seq, ATAC-seq) to
study basic and translational Treg cell immunoregulatory functions and development. Candidates are expected to be
independent and self-motivated with experience and/or knowledge of contemporary high-throughput sequencing techniques
as well as immunological mouse models, human blood sample processing as well as cell culture, flow cytometry and cell
sorting.Candidates must hold a doctoral degree (PhD, MD, or the equivalent) in molecular, cell biology, immunology or related
fields.

Those with experience in Primary Immunodeficiencies, mouse models of immunology, mammalian cell isolation, cell
culture, flow cytometry, in vitro gene manipulation, RNA isolation and handling, hands-on expertise in molecular biology and
transcription regulation are highly encouraged to apply. Performing high-throughput sequencing library preparation is highly
desirable. In addition, strong oral and written communication skills, excellent organizational and recordkeeping skills with high
attention to detail, the ability to work independently as well as collaboratively with others, personal and professional integrity
and flexibility in work scheduling are highly valued.

To apply, interested individuals should submit their CV, a cover letter outlining interests and accomplishments to Dr. LouisMarie Charbonnier : Louis-Marie.Charbonnier@childrens.harvard.edu
Salary will follow NIH guidelines commensurate with training and experience. Boston Children’s Hospital, Harvard Medical
School is an Affirmative Action/Equal Opportunity Employer