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Postdoctoral Research Fellow in Informatics, Cancer Genomics, and Biological Data Science 

Job summary: 

The Dietlein Lab (www.dietleinlab.org) is seeking applications for a fully funded Postdoctoral Fellowship position. Our lab is part of the Computational Health Informatics Program (CHIP) at Boston Children’s Hospital (BCH) and Harvard Medical School. We focus on data-driven precision cancer medicine – to decode the genomic principles of tumor development, overcome barriers to discovering actionable lesions in cancer genomes, maximize the potential of sequencing technologies in patient care, and innovate genome-inspired diagnostics and cancer therapies. Highlights of our research include: We developed one of the first algorithms for discovering noncoding drivers in cancer genomes (Science 2022), established a comprehensive resource of coding drivers in 11,873 patients (Nature Genetics 2020), created a platform for designing driver-directed combination therapies (Cell 2015), and led several clinical studies to enhance early-stage diagnoses of prostate cancer metastases in PET/CT imaging (JNM 2022). Examples of our most recent work can be found here: 

https://pubmed.ncbi.nlm.nih.gov/35389777/ https://pubmed.ncbi.nlm.nih.gov/32015527/ https://pubmed.ncbi.nlm.nih.gov/26140595/ https://pubmed.ncbi.nlm.nih.gov/35726091/ https://pubmed.ncbi.nlm.nih.gov/35121878/ https://pubmed.ncbi.nlm.nih.gov/33230298/ https://www.dietleinlab.org/publications 

About our lab: 

We are dedicated to training the next generation of exceptional scientists in our laboratory. Regardless of your future plans, it is at the heart of our mission as an academic laboratory that you thrive to the next level in your career. This includes guidance to establish a strong funding and publication record as well as dedicated mentorship for your personal career development. 

With your start in our lab, we tailor a training plan to your specific strengths and needs, develop actionable teaching goals, and identify potential co-mentors and required resources. Our teaching includes biweekly meetings, peer mentorship, and a joint seminar series. Besides a stellar scientific training environment and outstanding access to data and infrastructure resources, we provide our trainees with plenty of opportunities for their personal growth, such as career development classes, attending national and international conferences, and dedicated time for planning next steps in science, academia and beyond. 

All projects in our lab have immediate potential for clinical translational in view, but we know that it requires a long way to go from a computational finding to a clinical therapy. We consider mutual respect and open communication the glue that holds our lab together. Our regular social gatherings build team spirit, and town hall meetings identify issues that we can work on together. Our lab community creates an environment where we can thrive to our fullest potential. We know that cancer is a complicated puzzle, and we value that our scientists bring complementary pieces to the table from their different training backgrounds. We thrive on  collaboration, collegiality, and data sharing. While scientists maintain ownership of their project, we encourage collaborations between different disciplines, such as integrating computational and experimental strategies. As a team, we solve challenges that are impossible to overcome for a single discipline. Surrounded by Harvard, CHIP, Boston Children’s, Dana-Farber, and the Broad Institute, our lab provides an ideal environment for creativity, interdisciplinary collaborations, and your personal growth to thrive to your fullest potential in your career. 

We look forward to learning more about you and your story! 

Required Qualifications: 

– MD, PhD, or equivalent. Preferably in computational biology, biostatistics, genetics, applied mathematics, physics, biology, molecular medicine, or related fields.
– Demonstrated skills in methods or software development and analysis of biological data.
– Previous work with cancer biology or genomics data (preferred but not required) 

– Strong programming experience. Preferably in Python, R, Java, C++, or Matlab
– Strong publication record and scientific writing skills
– Ability to work as part of a larger, integrated team of scientists
– Because this training opportunity is funded by an NIH training program, it is open to US citizens, non-citizen nationals, or permanent residents (green card) only. If you do not fall into this category, we encourage you to submit your application to discuss other postdoctoral training opportunities in our lab. 

How to apply 

Interested applicants should submit the following documents to Felix Dietlein, MD PhD (felix.dietlein@childrens.harvard.edu):
– cover letter, including a personal statement, your prior research experience, and training goals – CV and publication record
– contacts of three references OR three letters of recommendation
– up to 3 highlighted publications (optional) 

We will start evaluating applications in December 2022 on a rolling basis until this position is filled. The start date for this position is April 20232 or earlier.
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law. 

Postdoctoral Associate, Program Evaluation and Research Development

Research Development at Boston University invites applicants for a postdoctoral associate focused on program evaluation and research development. The postdoc will gain training in the design, implementation, evaluation, and management of primarily training and workforce development programs involving graduate students, postdoctoral scholars, and faculty (e.g. Boston University’s Ignition Award program). However, the postdoc will also participate in the development and evaluation process for future programs that would benefit from a clear program evaluation approach.

This position is a three year postdoc position focused on program evaluation and development. In the first two years, the position will support program evaluation of existing training and workforce development programs at Boston University. The postdoctoral associate will design and implement evaluation plans and facilitate use of data toward improved outcomes and impact.  This will include developing and implementing evaluation methods based on existing program goals and metrics, analyzing qualitative and quantitative data, and developing data dashboards and publications that describe each program’s impacts. In the last year, the position will shift towards conceptualizing novel workforce development programs in collaboration with our team, and may include collaborating with staff and faculty to develop applications for grant funding opportunities.Required Skills

The postdoc’s primary responsibilities will be to:

  • Use a mixed methods evaluation approach to evaluate key strategic workforce and training programs at Boston University. This will involve both developing protocols that are shared across several programs as well as instruments or methods tailored to evaluate specific program goals and outcomes; (40%)
  • Analyze program outcomes data and develop data dashboards that will: inform Research Leadership and program faculty; enhance scholarly publications; and inform federal funding annual reporting requirements; (25%)
  • Publish scholarly work in peer-reviewed journals in collaboration with Research team members (25%)
  • Collaborate with Research Leadership to develop new workforce development programs, including program design, implementation, and evaluation. Collaboratively identify and develop applications for indpeendent funding to support new programs. (10%)

These activities will provide valuable experience for the Postdoctoral Associate in program design and management, and program evaluation and research. This training position is ideal for those interested in careers within academic administration, workforce development, or at university research centers with dedicated workforce components. The successful candidate will report to the Assistant Vice President and Assistant Provost of Research Development and PhD & Postdoctoral Affairs, and work closely with our Director of Technology Development and our Associate Vice President of Industry Engagement. 

This is a full-time, benefits-eligible appointment for three years with an anticipated start date in January 2023. To apply, please send a resume or CV and cover letter describing your background, qualifications, future goals, and why you believe you would be a strong fit for the position to sch1@bu.edu. Please be prepared to provide three references. Application materials will be considered on a rolling basis, but for full consideration, all materials must be received by November 1, 2022.

Applicants should have completed a PhD in education or a related social sciences discipline before starting the position, and have a strong interest in academic administration, workforce development, and/or program evaluation and research. The ideal candidate will have experience with qualitative and quantitative research methodologies and/or program evaluation. The candidate should have significant research-based experience and expertise in manipulating and analyzing large data sets with quantitative and text data, knowledge of survey design tools such as Qualtrics, NVivo (or other qualitative software), and/or SPSS (or other statistical analysis software). Effective project management skills (e.g., time management, problem solving, adaptability, and organization). Knowledge and skills required are obtained through a doctoral degree in public policy, public administration, biostatistics, education or evaluation-based research, or related field.

The individual should be able to work proactively and independently and must be comfortable managing competing project activities, deadlines, and outcomes. They also must possess strong communication and collaboration skills, and be able to work effectively with University leaders and faculty program directors.

Please note all newly hired staff and faculty will need to be in compliance with Boston University’s COVID-19 Vaccination and Booster Requirement within 30 days of date of hire. You must upload your vaccine documentation or request a medical or religious exemption (instructions). For further information on the University’s response to COVID-19, please visit the COVID-19 Resources site.

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, national origin, physical or mental disability, sexual orientation, gender identity, genetic information, military service, pregnancy or pregnancy-related condition, or because of marital, parental, or veteran status. We are a VEVRAA Federal Contractor.Job LocationBoston, United StatesPosition TypeFull-Time/RegularSalary GradeBased on experience

Apply here: https://bu.silkroad.com/epostings/index.cfm?fuseaction=app.jobinfo&jobid=310992&source=ONLINE&JobOwner=1016383&company_id=15509&version=1&byBusinessUnit=NULL&bycountry=0&bystate=0&byRegion=&bylocation=NULL&keywords=postdoctoral&byCat=&proximityCountry=&postalCode=&radiusDistance=&isKilometers=&tosearch=yes&city=

RNA Processing Lectures

The Tufts School of Graduate Biomedical Sciences is seeking a post-doc who can give a set of 3-4 lectures on RNA processing to early-stage Ph.D. students at Tufts University School of Medicine for this coming spring semester.

Other duties will include writing and grading an exam question on your lecture material and leading a paper-based discussion section.

There would also be the opportunity to help grade final research proposal papers.

The class is Biochemistry 230 and runs Mon and Wed from 9-11.

This is a wonderful way to get some teaching experience without being in charge of a full course.  Notes and slides from last year’s lectures will be available to help you prepare. A stipend will be provided.

For more information, please contact Prof. Amy S. Yee (amy.yee@tufts.edu); 617-636-6850.

Adjunct Lecturer(s) in Biotechnology and/or Evolution

Fisher College
Boston, MA
Type: Adjunct/Part-Time
Category: Biology

Job Description:

The fast-growing, innovative Biology Program at Fisher College is looking for adjunct faculty to teach SC225 Introduction to Biotechnology and/or SC402 Evolutionary Biology for the Spring 2023 semester. These courses are scheduled to run Mondays and Fridays, 2:00 PM – 3:15 PM, and Mondays and Wednesdays, 3:30 PM – 4:45 PM, respectively. Class starts on January 17th and ends on May 5th.

SC225 Introduction to Biotechnology (3 credits)

This course provides an introduction to the principles of biotechnology and its history. Molecular biotechnology techniques, including those required for recombinant DNA and gene cloning, and recombinant protein design and analysis, are emphasized and covered extensively. These techniques will be studied within the context of appropriate uses, limitations, and experiments that utilize specific techniques. The applications and ethical considerations of biotechnology are also covered including medical, microbial, plant, and forensic biotechnology applications. This course will provide real-world context and application-based learning for scientific principles, as well as highlight potential biotechnology-related career options in the biotechnological field.

SC402 Evolutionary Biology (3 credits)

This course provides an extensive and in-depth study of the history of evolutionary theory, evolutionary principles, and the application of evolutionary concepts to the field of biology and society. Geological, Paleontological, and historical breakthrough principles by Darwin are explored. Evolution is then explored on an individual basis, including the study of how traits are tracked and quantified and have evolved, quantified, and how they occur on a molecular basis to produce phenotypes. Key evolutionary concepts are covered, including: Drift, Selection, and Adaptation. Finally, the relevance of evolutionary concepts to society is studied, in the context of individual and societal behaviors, species, human evolution, and medicine that applies to evolutionary concepts.

Qualification:

The successful candidate will have the following:

  • a Master’s degree or ABD (Ph.D. preferred) in biological sciences or related fields, including biotechnology, biophysics, and biomedical engineering.
  • a record of successfully teaching undergraduate students.
  • a demonstrated ability to work effectively with diverse students and foster an inclusive learning environment.
  • the ability to work and communicate effectively with diverse community members, including students, professional staff, and faculty from a broad range of academic, socioeconomic, cultural, race, physical ability, age, neurodiversity, sexual orientation, gender identity, and other backgrounds.
  • an inclusive pedagogy in all delivery methods.

Responsibility:

The successful candidate will be responsible for:

  • preparing a syllabus for the course and distributing the approved syllabus to the students.
  • teaching lecture courses.
  • preparing quizzes and exams.
  • grading assignments and exams in a timely manner.

How to Apply:

Interested applicants should email a CV and cover letter to Seung-Hwan Kim, Ph.D., Assistant Professor, Biology Program Director (seung-hwan.kim@fisher.edu).

Fisher College:

At Fisher College (https://www.fisher.edu/), a private, not-for-profit institution located on Beacon Street in Boston’s Back Bay, we believe college should be more than just higher education—it should be a life-changing experience, an introduction to a much larger world of possibilities, knowledge, and expectations. Small class sizes, personalized attention, dedicated professors, and a world of experiences inside and outside the classroom make Fisher College the perfect place to earn your degree. Here, students can pursue their passion and follow their interests. Offerings include a wide variety of undergraduate and graduate degrees that allow students the opportunity to advance their knowledge in programs that prepare them for a lifetime of achievement.

Postdoctoral Fellowship Position: Stem Cell Program in Carla Kim Lab

The Kim Lab in the Stem Cell Program at Boston Children’s Hospital seeks a highly motivated postdoctoral research fellow, who will conduct research under the mentorship of Dr. Carla Kim, Professor of Genetics at Harvard Medical School, Harvard Stem Cell Institute Faculty Member, and Member of the Stem Cell Program at Boston Children’s Hospital.

The broad interest of the Kim Lab is to use stem cell biology to increase our understanding of how mechanisms governing normal lung biology are impacted in lung disease and lung cancer.

Our lab utilizes co-culture organoid systems that allow us to define how mouse and human lung epithelial progenitor cells are regulated by cell-cell communication. Multiple projects are aimed at using these systems to shed light on lung cancer, emphysema, COPD, idiopathic pulmonary fibrosis and other lung diseases. The position offers an exciting opportunity to work closely with scientists and medical professionals in the highly collaborative and stimulating environment of the Stem Cell Program at Boston Children’s Hospital located in the vibrant Longwood / Harvard Medical Area.

There are several projects in the Kim lab for postdoctoral research fellows, including but not limited to:

  • Transplantation of lung organoids to repair damaged lungs. The Kim lab is exploring the transplantation of healthy lung organoids as a tool for understanding lung stem cell biology and as a possible means to future cell-based therapy in diseased lungs.
  • Organoid models of early stage lung cancer. We are using lung organoids that carry tumorigenic mutations to model the early steps of lung adenocarcinoma and devise new strategies to impair the progression of small lesions to full malignant growth.

Recent Kim Lab publications:

Progenitor potential of lung epithelial organoid cells in a transplantation model.

Louie SM, Moye AL, Wong IG, Lu E, Shehaj A, Garcia-de-Alba C, Ararat E, Raby BA, Lu B, Paschini M, Bronson RT, Kim CF. Cell Rep. 2022 Apr 12;39(2):110662. doi: 10.1016/j.celrep.2022.110662.

Louie SM, Moye AL, Wong IG, Lu E, Shehaj A, Garcia-de-Alba C, Ararat E, Raby BA, Lu B, Paschini M, Bronson RT, Kim CF. Cell Rep. 2022 Apr 12;39(2):110662. doi: 10.1016/j.celrep.2022.110662.

Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells.

Dost AFM, Moye AL, Vedaie M, Tran LM, Fung E, Heinze D, Villacorta-Martin C, Huang J, Hekman R, Kwan JH, Blum BC, Louie SM, Rowbotham SP, Sainz de Aja J, Piper ME, Bhetariya PJ, Bronson RT, Emili A, Mostoslavsky G, Fishbein GA, Wallace WD, Krysan K, Dubinett SM, Yanagawa J, Kotton DN, Kim CF. Cell Stem Cell. 2020 Oct 1;27(4):663-678.e8. doi: 10.1016/j.stem.2020.07.022. Epub 2020 Sep 4.

BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency.

Gupta M, Concepcion CP, Fahey CG, Keshishian H, Bhutkar A, Brainson CF, Sanchez-Rivera FJ, Pessina P, Kim JY, Simoneau A, Paschini M, Beytagh MC, Stanclift CR, Schenone M, Mani DR, Li C, Oh A, Li F, Hu H, Karatza A, Bronson RT, Shaw AT, Hata AN, Wong KK, Zou L, Carr SA, Jacks T, Kim CF. Cancer Res. 2020 Sep 15;80(18):3841-3854. doi: 10.1158/0008-5472.CAN-20-1744. Epub 2020 Jul 20.

Requirements:

The candidate should have a Ph.D. or an M.D./Ph.D. No postdoctoral experience is required.

How to apply:

Interested applicants should email their CV, a cover letter indicating research experience, interests and goals, and names/contact information for at least three academic references to the Dr. Carla Kim at Carla.Kim@childrens.harvard.edu

Multiple Tenure-Track Faculty Positions at The BioFrontiers Institute, University of Colorado Boulder

The BioFrontiers Institute at the University of Colorado Boulder is pleased to announce a multi-position faculty hiring initiative. As an interdisciplinary research institute with global impact, we seek talented, ambitious individuals from diverse backgrounds with boundary-pushing vision in the life sciences, physical sciences, computational biology, or bioengineering. We are particularly interested in applicants whose work intersects with the institute themes of regenerative biology & engineering, degenerative diseases, infectious diseases, computational biology, or Down syndrome. Areas of interest include but are not limited to: stem cell biology and organoids, tissues and organs on a chip, biomaterials, tissue engineering, diagnostics and drug delivery, immunoengineering, multiscale and multimodal optical imaging, biomechanics, and platform development for translational medicine. We encourage creative and collaborative individuals, particularly women and people identifying with underrepresented minority groups, to apply.

The BioFrontiers Institute integrates faculty from 11 academic departments across 2 colleges to address significant problems in biology and medicine with interdisciplinary approaches. Successful candidates will have a tenure home in either the College of Engineering and Applied Science or in the College of Arts and Sciences. They will develop an independent, internationally recognized research program that is synergistic with other programs of the University of Colorado community. Duties will include research, teaching, and service. Candidates must have a Ph.D. and/or M.D. as well as a demonstrated commitment to teaching and fostering diversity through inclusive practices.

All applications received by November 1, 2022 will receive full consideration. Review will continue until December 1, 2022. The University of Colorado Boulder conducts background checks for all final applicants. As an Equal Opportunity/Affirmative Action employer, the University of Colorado is committed to diversity and equity in education and employment and is sensitive to the needs of dual-career couples.

Application materials will be accepted electronically through the CU Boulder Jobs Site (position #42958) starting in October 2022: https://jobs.colorado.edu/jobs/JobDetail/?jobId=42958

Postdoctoral Scholar

Department of Immunology
Tufts University, School of Medicine
Boston, Massachusetts

Department Overview

The Department of Immunology maintains research programs that focus on translational and basic research in areas relevant to human disease. Our goal is to become a world-class center for the study of inflammation and the targeted development of novel therapeutics for both treatment and prevention of immune-mediated diseases. The strength of the department lies with an integrated faculty interested in understanding how immunological, physiological and metabolic pathways interact to produce dysregulated, innate and adaptive host responses in a wide array of chronic diseases. These include autoimmunity, cardiovascular disease, transplantation, infectious diseases, and others.

Position Description

The Postdoctoral Scholar will work closely with Dr. Bernard Arulanandam (Professor of Immunology, Vice Provost for Research) and his research team to develop novel immunotherapeutics against human bacterial pathogens including Chlamydia and Acinetobacter.

Primary focus in Dr. Arulanandam’s research is to understand the immunopathogenesis of Chlamydia trachomatis, the leading cause of sexually transmitted bacterial disease worldwide.  The postdoc. will lead the development of an exciting novel human genital organoid chlamydial infection system to dissect host-pathogen interaction. The long-term research goal is to identify immune targets from this organoid infection system for further development of therapeutics to reduce chlamydial pathogenesis and enhance host protective immunity. This postdoc. candidate will also participate in the development of preventive vaccines and antibody-based treatment against Acinetobacter baumannii, an important multidrug-resistant pathogen of the general population and military personnel.

The successful candidate will be a highly motivated individual able to work efficiently and productively in a fast-paced, multifaceted research environment. Main responsibilities of the candidate include design and execution of research projects, presentation and publication of research results, identification of new grant opportunities and playing a major role in the writing and submission of grant applications.

The initial appointment will be for one year, with the possibility of extension for an additional 2, made on a year-by-year basis, dependent on funding.

Years of related experience: 1-3 years of experience

Required Education: Ph.D.

Required computer skills: working knowledge of Excel, Prism-GraphPad.

Other: Initiative, problem-solving skills, multi-tasking skills, time management skills, and excellent collegiality and collaborative skills are needed.

Preferred Qualifications:

The preferred candidate should have a doctorate in a field related to cell biology, immunology or microbiology. One to three years of postdoctoral experience is preferred. A record of published scientific research, advanced methodological skills, scientific writing, and scientific presentations are ideal. Successful experiences in grantsmanship and laboratory management is preferred.

Please send a letter of application, curriculum vitae, 2-3 publications, and the names and contact information of three references to: Angela Lu;  angela.lu@tufts.edu

Senior Staff Scientist

BOSTON CHILDREN’S HOSPITAL
HARVARD MEDICAL SCHOOL

We are seeking a full-time Senior Scientist with a core competence in Quantitative Clinical Pharmacology and Pharmacokinetics and experience in laboratory management. The successful candidate will conduct and supervise assay development and performance, and modeling of the acquired data. Our overarching goals are for the PK Laboratory Senior Staff Scientist to conduct and supervise assay development and performance, and modeling of the acquired data. Other important goals include enhancement of departmental research that could involve such data, by teaching, collaboration, and development of research projects. Candidates are highly encouraged to explore their own ideas, and present their work at conferences.

Responsibilities and Qualifications:

Laboratory:

  • Ensures laboratory certification based on national standards.
  • According to established protocols, good laboratory practices (GLPs) and assigned schedules, supervises and performs a variety of routine laboratory analyses and procedures, utilizing standard laboratory equipment including HPLC, LCMS.
  • Maintains equipment and organizes the laboratory’s supplies; provides personnel training and guidance on experimental design and experimental approaches.
  • Integrates systems and processes to ensure adequate operation of the laboratory, and safe, accurate and timely provision of pharmacokinetic and pharmacometric services.
  • Establishes budgetary requirements for the provision of pharmacometrics and pharmacokinetics studies, including staffing requirements and technological needs.
  • Supervises and bi-annually evaluates support staff in the laboratory.

Research:

  • Participates in collaborative research to improve patient care and advance academic productivity.
  • Integrates and enhances interactions between the basic sciences, clinical sciences and pharmacy practice in areas of research, education, and service.
  • Translates novel technologies into clinical investigation and collaborates with other basic researchers or clinical investigators.
  • Communicates teaching and research activities.
  • Keeps abreast of the latest developments in the field; and identifies and utilizes emerging research technologies.
  • Helps accomplish the long-term research goals of the laboratory, including assisting in the preparation of grant applications.

Pharmacy:

  • Provides consultative pharmacokinetic/pharmacodynamics service in conjunction with the Department of Pharmacy at Boston Children’s Hospital. This will include patient specific as well as population-based queries. Additionally, this Senior Scientist will oversee the development and implementation of pharmaceutical analytic services for dosage form development, stability indicating assays and other biopharmaceutic analyses consistent with current USP standards.

Qualification:

  • At least 5 years of experience and PharmD or Ph.D. in pharmacology.
  • Postdoctoral experience and strong academic credentials in the discipline of pharmacology.
  • Experience in analytical techniques using human, animal, and in vitro samples (e.g., HPLC, LC-MS, bioassays).
  • Experience in pharmacokinetic modeling.

IZABELA LEAHY, PhD, MS, RN
Executive Director Associate Chair in Anesthesia Department of Anesthesiology,
Critical Care & Pain Medicine (617) 512-3094 Izabela.Leahy@childrens.harvard.edu

Research Scientist – Stem Cell Modeling and Genome Editing

Description

The Collaborative Center for X-Linked Dystonia-Parkinsonism (CCXDP) is a global disease consortium based at Massachusetts General Hospital that is focused exclusively on a rare neurodegenerative disorder endemic to the Philippines. We are an international coalition of scientists, physicians, and industry partners throughout North America, Europe, and Asia all working together to solve X-Linked Dystonia-Parkinsonism (XDP), a severe movement disorder. The hub of our network is a group of core investigators at MGH with affiliations spanning Harvard Medical School, the Harvard Stem Cell Institute, and the Broad Institute.

CCXDP is seeking a Research Scientist to lead a broad range of studies applying genome editing technologies to interrogate DNA sequence variants linked to XDP and related movement disorders in induced pluripotent stem cell (iPSC) models. You will work closely with a dynamic team including senior investigators, junior faculty members, PhD-level staff scientists, research technicians, and students.

What you’ll do:

  • Perform studies of induced pluripotent stem cells using CRISPR-based genome editing methods to alter disease-related DNA sequence variants of interest.
  • Differentiate engineered iPSC lines towards neuronal and glial lineages using established protocols.
  • Characterize cellular phenotypes in engineered iPSCs using a range of molecular, biochemical, and/or imaging-based assays
  • Investigate, create, and develop new methods and technologies for research advancements.
  • Prepare written data reports, including methodology, figure preparations, written description of the study in the form of manuscripts and/or progress reports.
  • Contribute to research presentations at local, national, and international meetings.
  • Organize and/or draft material for the preparation of research papers, manuscripts, or other documents for publication and/or presentation.

Requirements

  • Msc (required) or PhD (preferred) in relevant biomedical discipline with 3-5 years of experience in a related research field.
  • Experience with mammalian tissue culture with an emphasis on iPSCs
  • Experience with CRISPR-based genome editing methods and related molecular genetic techniques.
  • Ability to work independently and as a team member.
  • Excellent organizational and communication skills
  • Ability to prioritize tasks, set deadlines, and adapt to shifting priorities in response to changing deadlines and needs of the lab.
  • Ability to function with speed, precision, and an understanding of theory behind protocols and experiments.

To apply visit: https://partners.taleo.net/careersection/ex/jobdetail.ftl?job=3209030&tz=GMT-04%3A00&tzname=America%2FNew_York

Computational postdoc position at Boston Children’s Hospital and Harvard Medical School

The Gutierrez-Arcelus Lab at Boston Children’s Hospital and Harvard Medical School (gutierrezarceluslab.com) is seeking a dry lab postdoctoral research fellow to work on systems immunology of immune mediated diseases. This is a fully funded position for at least two years. The postdoctoral fellow will be conducting research mainly in collaboration with Dr. Janet Chou’s lab to understand the role of obesity in multisystemic inflammatory syndrome in children (MIS-C). This will involve analyzing single cell and other functional genomics datasets, as well as genetic variation data.

The Gutierrez-Arcelus lab is an interdisciplinary group that utilizes genetics and multiomics quantitative approaches to deepen our understanding of human gene regulation,
how it varies between individuals, and how these regulatory differences contribute to immune-mediated disease. The lab is part of the Division of Immunology at Boston Children’s Hospital, and Harvard Medical School, and is affiliated with the Broad Institute. We have both dry and wet lab space, and we collaborate with immunology laboratories. The Boston area is a vibrant and dynamic scientific community that offers unique opportunities for scientific growth.

Successful candidates must hold (or soon receive) a Ph.D., M.D. or M.D/Ph.D. degree in the field of genomics, biostatistics, bioinformatics, or other quantitative sciences; and should have a track record of research achievements and ability to work independently and collaboratively in a team. Other desired (but not required) skills for this position are

a) transcriptomics or epigenomics background,

b) immunology background;

c) human genetics background.

Interested applicants should email mgutierr@broadinstitute.org with their CV.

Postdoctoral Research Fellow for the Alex Cuenca Lab at BCH

The Cuenca lab at Boston Children’s Hospital is seeking a highly motivated postdoctoral research fellow that is interested in innate immunity, allograft immunity, and therapeutics designed to delay allograft rejection/generate allograft tolerance. Our lab’s overall goal is to understand how to shape the transplant recipient’s bone marrow and innate immunity to provide allograft tolerance.

Preferred qualifications include:
1) Proficiency and knowledge of immunological assays (ie ELISA, Luminex, and Flow Cytometry)
2) Ability to work independently and as part of a team
3) Animal handling, breeding, and surgical skills
4) Basic statistical methods
5) 0-3 years of post-doctoral expertise
6) MD and/or PhD

Salary is competitive and commensurate with years of post-doctoral experience/qualifications

Please send CV, statement of interest, and 3 references to:
Alex Cuenca, MD PhD (alex.cuenca@childrens.harvard.edu)

Postdoctoral Researchers

Tufts University has openings for three post-doctoral researchers to engage in cross-cutting projects focusing on the development of “precision” models and algorithms with applications in learning science, nutrition, and medicine. These three domains are seeing an explosion in the types and quantities of information that can be collected to provide insight into various aspects of human physiology and psychology. Practitioners in these fields are eager to use these data to understand the dynamics of a wide variety of processes taking place both within and between people and make timely and accurate predictions at the scale of the individual. The characteristics of the data however render traditional analysis methods, largely concerned with population level statistics, inadequate. Many of these challenges arise from issues of heterogeneity. Some sources such as wearables provide data continuously. Others yield measurements at only a few discrete points in time (e.g., biomarkers derived from saliva samples) while audio and video are examples of data that may be provided in noncontiguous intervals of varying length. Most of these data are only indirectly related to the phenomena of interest with no explicit model linking the two as is the case for student work in the context of learning, electronic medical records for nutrition or medicine, or the results of questionnaires in all applications of interest. Finally, although the quantity of data collected about any one individual may be relatively large, practical considerations make the number of participants associated with most studies relatively small, on the order of tens at most making these simultaneously “big” and “small” data problems. 

While learning, nutrition, and medicine each possess unique characteristics, the common challenges just described strongly suggest that an integrated approach to “precision analytics” will provide a fruitful path forward. Thus, we are looking for three PhD-level scientists with interests in pioneering rigorous and at the same time useful solutions to the problems outlined above. Each researcher will lead the effort in a specific domain, and the group as a whole will work collaboratively to exploit underlying commonalities across the different disciplines. Successful candidates will have a PhD in a quantitative discipline such as applied mathematics, statistics, signal processing, machine learning, or physics with a track record of high-quality publications in relevant journals and peer reviewed conferences. We seek individuals who will advance the state of the art in machine learning, data science, artificial intelligence etc. in a manner that also support the research goals and interests of our application domain partners drawn from

  • The Tufts Center for Applied Brain and Cognitive Sciences
  • The Tufts Institute for Research on Learning and Instruction
  • Jean Mayer USDA Human Nutrition Research Center on Aging
  • The Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance

For more information about this position, please email Prof. Eric Miller at eric.miller@tufts.edu. 

Interested candidates should provide Prof. Miller with a copy of their CV, list of references, cover letter, and copies of relevant articles, theses, technical reports etc.

Instructor-Fixed Term

Biochemistry & Molecular Biology

Advertised: Apr 20, 2022 Eastern Daylight Time
Applications close: Apr 20, 2024 Eastern Daylight Time

Apply here: https://careers.msu.edu/en-us/job/510239/instructorfixed-term

This is a 12-month, fixed-term (non-tenure track) position with an expected start date in August 2022. The successful candidate will be an innovative and engaging educator who will implement the online instruction of our 200-level and 400-level comprehensive biochemistry courses for non-majors that are offered in the fall, spring, and summer semesters. These popular courses have large enrollments of MSU students who are health- and life-science related majors, chemical engineers, and also serve continuing education students from outside the university. The primary responsibility of the successful candidate will be to manage and maintain these two established online offerings. Specific duties include the delivery of current materials, including course lectures and learning activities, the development and administration of course exams, and evaluation of other student work. The successful candidate will also hold office hours, mentor students, and train and supervise course teaching assistants. We anticipate that, over time, the successful candidate will update the courses regularly by incorporating new scientific discoveries, taking advantage of emerging technologies in developing and presenting course material, and collaborating with other educators as the online courses evolve. We also highly encourage engagement in Discipline-Based Education Research and subject matter pedagogy. The College and Department are committed to building and supporting an equitable and inclusive community of faculty, staff, and students. The department is especially interested in receiving applications from candidates who have demonstrated a commitment to diversity and inclusion and who may bring perspectives from a nontraditional educational background and/or an understanding of the experiences of persons from underrepresented groups.

Equal Employment Opportunity Statement

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, citizenship, age, disability or protected veteran status.

Required Degree

Masters -Biochemistry, Molecular Biology, or closely related field

Desired Degree

Doctorate -Biochemistry, Molecular Biology, or closely related field

Minimum Requirements

Masters degree required. A doctorate is preferred in biochemistry, molecular biology or closely related field.

Experience in teaching science courses at the college or university level. Experience teaching diverse populations of students and/or evidence of commitment to professional development around diversity, equity, and inclusion topics.

Desired Qualifications

Proficiency in biochemistry and molecular biology. Demonstrated effective teaching skills such as experience in online teaching, which may include video production and delivery, familiarity with learning management systems like Brightspace D2L or other education technologies that support online learning, knowledge of accessibility standards and use of quality assurance tools such as Quality Matters or OLC Quality Scorecard, experience with teaching in large-enrollment course, experience in curriculum development, examples of collaboration during course instruction curriculum development or in other professional contexts, evidence of professional development, participation in or familiarity with scholarship of teaching and learning (SOTL) or discipline based educational research (DBER).

Required Application Materials

Applicants should submit the following documents to jobs.msu.edu (posting 773205):

  • cover letter
  • curriculum vitae
  • scientific writing sample (e.g., research manuscript, medical communication, technical report, science blog post, news article)
  • teaching portfolio (limited to 10 pages) describing past roles and responsibilities based on a brief narrative and supporting information such as syllabi, assessments, student evaluations, developed course curricula and course materials, including any involvement in online teaching. A representative short (5 to 10-minute) lecture video or other previously delivered online material is encouraged (if not providing public links for online material, please contact the Chair of Search Committee for alternative options).   
  • teaching philosophy (limited to 2 pages) with documentation of philosophy implementation and  contributions to Diversity, Equity, and Inclusion (DEI). Thoughts on the particular challenges and opportunities of online teaching are highly encouraged. 
  • contact information for 3 references in the cover letter

Together-we-will Statement

The university is requiring all MSU students, faculty and staff to be vaccinated against COVID-19 with limited exceptions. Learn more at: https://msu.edu/together-we-will/

Special Instructions

The applicant should also provide contact information for 3 references in the cover letter. Please direct questions regarding the position to Dr. Michael Feig, Chair of the Search Committee (feig@msu.edu).

Review of applications will begin on May 16 and continue until a suitable candidate is identified.

Review of Applications Begins On

05/16/2022

Website

https://bmb.natsci.msu.edu/

Department Statement

The missions of the Department of Biochemistry & Molecular Biology at Michigan State University are to discover and transfer new knowledge about the molecular basis of life through basic and cross-disciplinary biomolecular science research while maintaining a collegial and fertile learning environment. Additional information about the BMB Department, including descriptions of current courses, can be found at the BMB departmental website.  https://bmb.natsci.msu.edu/

MSU Statement

Michigan State University has been advancing the common good with uncommon will for more than 160 years. One of the top research universities in the world, MSU pushes the boundaries of discovery and forges enduring partnerships to solve the most pressing global challenges while providing life-changing opportunities to a diverse and inclusive academic community through more than 200 programs of study in 17 degree-granting colleges.

RESEARCH SCIENTIST I, METHODS DEVELOPMENT LAB, BROAD INSTITUTE

Apply Here: https://broadinstitute.wd1.myworkdayjobs.com/broad_institute/job/CambridgeMA/Research-Scientist-I_3690?shared_id=95f2b011-c7c7-45f6-bb89-9c239ad5c925

The combination of biotechnological and computational advances over the past decade has substantially augmented our ability to create high-performance methods, thereby driving biological discovery and development of transformative medical breakthroughs. While this accelerated pace of methods development offers great promise, the rapid expansion of novel techniques gives rise to new challenges regarding adoption and effective implementation. To capitalize on these exciting technological advances with a strong emphasis on driving novel methods adoption, the Broad Institute has formed the Methods Development Lab, a highly collaborative entity to identify high-value scientific frontiers and generate and disseminate high-performance end-to-end productionized approaches to the community.

The Research Scientist is responsible for driving the development of novel molecular techniques related to -omic technologies that will positively impact the Broad Institute science and technological capabilities and offerings within the Genomics Platform. The Research Scientist will lead collaborative projects with Broad Programs and Platforms, with an emphasis on Cell Circuits, the Klarman Cell Observatory, Gene Regulation Observatory, Immunology Program, Data Sciences Platform, and Genetic Perturbation Platform. In addition, the Research Scientist will keep current with the state of the field and interests/needs of Broad researchers and work with the Methods Development Lab Group Leader to conceptualize, prioritize, and then develop new methods. The Research Scientist will work closely with Genomics Platform R&D, Automation, LIMS, production teams, and Data Sciences Platform to translate novel methods into production scale processes to make them available to the community.

RESPONSIBILITIES

• Drive novel technology development projects within specific areas as agreed upon with the MDL Group Leader.

• Help evaluate new -omic technologies to determine utility, impact, fit with Genomics Platforms capabilities and interests.

• Work closely with DSP computational biologists to create analytic methods for novel technologies and novel resources for the community. • Mentor junior team members and serve as a resource for molecular biology techniques.

• Oversee research associates and computational biologists working on MDL projects.

• Assist in obtaining federal, philanthropic, institutional, or industrial funding opportunities for technology development.

• Publish novel methods in collaboration with Broad scientists.

• Seek intellectual property protection for inventions that are conceived of or developed while a member of the GP. SKILLS AND ABILITIES

• Must be passionate and deeply committed to the mission of the Methods Development Lab and the entire Broad.

• Must be forward-thinking and innovative, with a nimble scientific/technical mind, able to rapidly develop and execute on creative solutions.

• Excellent communicator in written and verbal form.

• Deep molecular biology experience.

• Strong data analysis skills.

QUALIFICATIONS

• PhD in Molecular Biology

• Proven experience in writing successful proposal for funding of technology development

Apply: https://broadinstitute.wd1.myworkdayjobs.com/broad_institute/job/Cambridge-MA/ResearchScientist-I_3690?shared_id=95f2b011-c7c7-45f6-bb89-9c239ad5c925

Senior Staff Scientist

POSTDOCTORAL ASSOCIATE, VALLABH/MINIKEL LAB, BROAD INSTITUTE

The Vallabh/Minikel lab at the Broad Institute of MIT and Harvard seeks an independent Postdoctoral Associate motivated to impact human health by driving multiple projects of therapeutic and translational importance. This initiative is led by Dr. Sonia Vallabh and Dr. Eric Minikel, who became scientists in response to Sonia’s own genetic test report. The goal of our work is to discover, develop, characterize and advance effective treatments for prion disease, a rapidly fatal and currently incurable neurodegenerative disease.

You can read more about our mission here: http://www.vallabhminikel.org/

There are a number of projects in the lab for which an incoming postdoc could serve as champion. Many revolve around cell and tissue-based experiments aimed at illuminating drug mechanism of action and/or in vivo characterization of therapeutic activity in the rodent brain. Mechanistic studies will require the ability to generate and test new hypotheses using a range of in vitro and cell culture systems. In vivo experiments will require both deep pharmacological characterization of drug distribution and activity and proof-of-concept efficacy studies in disease models. The results should inform and enable the near-term development of human therapeutics for a currently untreatable disease.

The position will require several skill sets, many of which can be learned on the job, but the ideal candidate will come with experience in at least a few of the following areas: live animal handling and surgery; tissue harvest, preparation, dissection and staining; immunohistochemistry (IHC); tissue culture, immunofluorescence (IF), cloning, and transfection; quantifying RNA and protein (ddPCR, qPCR, ELISA, Western blots), production and characterization of recombinant protein.

A background in neuroscience, molecular biology and/or chemical biology will be extremely helpful.

The successful candidate will be able to take leadership of projects in a largely self-directed environment and will be ready to supervise a research assistant and to effectively manage relationships with vivarium staff, industry collaborators, contract research organizations, and other academic groups. A keen eye for statistical rigor is essential, and proficiency in data analysis is a plus.

REQUIREMENTS • A PhD in molecular biology, neurobiology, or an allied field. • Exquisite attention to detail and organizational capacity. • Enthusiasm for working as part of a team sharply focused on therapeutic outcomes and translation to human clinical trials. • We encourage candidates to apply as early as possible and will review applications on a rolling basis. Required application documents include a cover letter and CV. Please write a cover letter! Our lab is a unique environment, and we want to get a feel for why you are interested in working here in particular, out of all the labs out there. References will be requested on follow-up. We regret that we will not be able to reply to every applicant.

Contact: Sonia Vallabh at svallabh@broadinstitute.org

POSTDOCTORAL SCHOLAR

A postdoctoral position is available for an enthusiastic scientist to work in the area of regulatory T cell immunology. The position is located at the division of Immunology, Boston Children’s Hospital and Harvard Medical School under the supervision of Dr. Louis-Marie Charbonnier. This lab focuses on elucidating the mechanisms involved in the breakdown of immune tolerance in monogenic disorders of immunity, autoimmune diseases and allergic inflammatory disorders, with a
particular focus on the role of regulatory T cells in disease athogenesis. More specifically, the projects involve the regulatory circuitries underlying Treg cell fate decisions, Treg cell heterogeneity and reprogramming as well as metabolic and molecular therapeutics to promote immune tolerance, in the context of autoimmunity, Hyper IgE syndrome and Primary Immunodeficiencies.

Relevant articles :
1- Charbonnier LM, Wang S, Georgiev P, Sefik E and Chatila TA. Control of Peripheral Tolerance by Regulatory T CellIntrinsic Notch signaling. Nat. Immunol. 2015 Nov;16(11):1162-73
2- Charbonnier LM, Cui Y, Stephen-Victor E, Harb H, Lopez D, Bleesing JJ, Garcia-Lloret MI, Chen K, Ozen A, Carmeliet P,
Li MO, Pellegrini M, Chatila TA. Functional reprogramming of regulatory T cells in the absence of Foxp3. Nat Immunol. 2019
Sep;20(9):1208-1219
3- Zemmour D, Charbonnier LM, Leon J, Six E, Keles S, Delville M, Benamar M, Baris S, Zuber J, Chen K, Neven B, GarciaLloret MI, Ruemmele F, Brugnara C, Cerf-Bensussan N, Rieux-Laucat F, Cavazzana M, André I, Chatila TA, Mathis D, Benoist C.
Single cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations. Nat
Immunol. 2021 May;22(5):607-619.
4- Abdel-Gadir A, Stephen-Victor E, Gerber GK, Noval Rivas M, Wang S, Harb H, Wang L, Li N, Crestani E, Spielman S,
Secor W, Biehl H, DiBenedetto N, Dong X, Umetsu DT, Bry L, Rachid R, Chatila TA. Microbiota therapy acts via a regulatory T
cell MyD88/RORγt pathway to suppress food allergy. Nat Med 2019 Jul;25(7):1164-1174.

This position is ideal for an individual with high interest in high throughput methodologies (scRNA-seq, ChIP-seq, ATAC-seq) to
study basic and translational Treg cell immunoregulatory functions and development. Candidates are expected to be
independent and self-motivated with experience and/or knowledge of contemporary high-throughput sequencing techniques
as well as immunological mouse models, human blood sample processing as well as cell culture, flow cytometry and cell
sorting.Candidates must hold a doctoral degree (PhD, MD, or the equivalent) in molecular, cell biology, immunology or related
fields.

Those with experience in Primary Immunodeficiencies, mouse models of immunology, mammalian cell isolation, cell
culture, flow cytometry, in vitro gene manipulation, RNA isolation and handling, hands-on expertise in molecular biology and
transcription regulation are highly encouraged to apply. Performing high-throughput sequencing library preparation is highly
desirable. In addition, strong oral and written communication skills, excellent organizational and recordkeeping skills with high
attention to detail, the ability to work independently as well as collaboratively with others, personal and professional integrity
and flexibility in work scheduling are highly valued.

To apply, interested individuals should submit their CV, a cover letter outlining interests and accomplishments to Dr. LouisMarie Charbonnier : Louis-Marie.Charbonnier@childrens.harvard.edu
Salary will follow NIH guidelines commensurate with training and experience. Boston Children’s Hospital, Harvard Medical
School is an Affirmative Action/Equal Opportunity Employer