In the previous unit, we focused on adaptations and situations that contribute to microbes being pathogenic. We emphasized the idea that pathogenicity is a host–microbe interaction and that highly pathogenic microbes have adaptations that make them virulent. In this unit we will explore how an infection leads to symptoms and illness. The students will learn the mechanisms of host cell damage by microbes and how pathogens lead to impairment of host systems via disrupting structure and function.
- 4.1: Why do we feel sick – how pathogens cause direct and indirect damage
- 4.2: Toxins – Botox, tetanus, hamburger disease and MRSA
- 4.3: How do bacteria adapt to become pathogens? the adaptation auction
- 4.4: How do viruses make us sick – viral replication
- 4.5: How do viruses adapt? antigenic shift and drift and the flu pandemic
- 4.6: Designing an antiviral drug – the challenge of HIV