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Lesson 5.2 – Evolving pathogens — the adaptive immune system

This lesson transitions from innate immune responses to adaptive responses. It deals with the three complex principles of adaptive immunity: a) Each B and T cell can recognize only one ligand; b) each B and T cell recognizes this ligand with a unique receptor that is produced randomly; and c) these receptors are on a single B or T cell, so they need to clonally expand before responding to a threat. To understand the concept that B and T development is molecular evolution, students cut and paste antibodies randomly, then a pathogen is revealed to see if someone created an antibody specific for that pathogen (antigen).

Teacher Prep

5.2 Classroom Materials

5.2 Alternative Approaches

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