Patients on APAP are warned to have no more than three alcoholic drinks per day (12). Ethanol in conjunction with APAP is known to dramatically increase the risk of liver damage compared to digesting APAP alone. This is because alcohol increases the concentration of CYP2E1 in liver cells, causing APAP to be oxidized faster. The result is a sudden influx of NAPQI in liver cells, which overwhelms liver cell storage of GSH. If NAPQI depletes GSH stores and the production of NAPQI exceeds that of GSH, the hepatotoxic substance accumulates and kills liver cells (15). Alcohol, like many other drugs detoxified by the liver, is also a substrate of CYP2E1. It is known to induce CYP2E1 activity by protein stabilization (18). This is especially apparent at higher concentrations of ethanol when liver cells are unable to efficiently metabolize ethanol with alcohol dehydrogenase alone, which provides justification for the FDA’s warning on all products containing APAP (5).
Figure 19: Pathway for APAP Metabolism: NAPQI accumulates when GSH stores are depleted. Patients who overdose on APAP are treated with NAC to stimulate GSH production.
If you could include in the figure (or in another figure) the cascade of APAP being oxidized faster leading to NAPQI flowing into liver cells leading to etc etc, I think that would help the readers conceptualize the series of events that leads to liver cell death/liver damage.
Aw, this was a very nice post. In concept I wish to put in writing like this additionally ? taking time and precise effort to make an excellent article? however what can I say? I procrastinate alot and on no account seem to get one thing done.
very good publish, i certainly love this web site, keep on it
You made some respectable factors there. I regarded on the web for the problem and found most people will go along with along with your website.
Hey There. I discovered your blog using msn. That is a really smartly written article. I?ll be sure to bookmark it and return to read more of your helpful info. Thank you for the post. I?ll certainly return.
I’m in awe of the author’s capability to make complicated concepts accessible to readers of all backgrounds. This article is a testament to her expertise and passion to providing valuable insights. Thank you, author, for creating such an captivating and illuminating piece. It has been an absolute pleasure to read!
Hey just wanted to give you a quick heads up and let you know a few of the images aren’t loading correctly. I’m not sure why but I think its a linking issue. I’ve tried it in two different internet browsers and both show the same results.
I have seen many useful points on your web site about computers. However, I’ve got the opinion that netbooks are still not nearly powerful enough to be a good option if you usually do jobs that require plenty of power, including video croping and editing. But for web surfing, word processing, and the majority of other prevalent computer functions they are just fine, provided you don’t mind the screen size. Thank you sharing your thinking.
I?ve read several good stuff here. Certainly worth bookmarking for revisiting. I surprise how much effort you put to make such a wonderful informative site.
Thanks for your write-up on the traveling industry. I would also like contribute that if you are one senior taking into account traveling, its absolutely crucial that you buy traveling insurance for older persons. When traveling, seniors are at greatest risk being in need of a health emergency. Buying the right insurance coverage package for one’s age group can safeguard your health and provide peace of mind.
Thanks for your article. I would like to say that the health insurance dealer also works well with the benefit of the coordinators of the group insurance policies. The health insurance agent is given a long list of benefits sought by someone or a group coordinator. Such a broker may is hunt for individuals or even coordinators which usually best complement those wants. Then he gifts his ideas and if each party agree, this broker formulates an agreement between the two parties.
Thanks for expressing your ideas listed here. The other thing is that any time a problem arises with a computer system motherboard, individuals should not have some risk associated with repairing that themselves for if it is not done correctly it can lead to permanent damage to the complete laptop. It’s usually safe just to approach your dealer of the laptop for any repair of that motherboard. They’ve technicians who may have an competence in dealing with notebook motherboard difficulties and can make right analysis and accomplish repairs.
One thing is that often one of the most widespread incentives for applying your credit cards is a cash-back or maybe rebate offer. Generally, you get 1-5 back with various purchases. Depending on the credit cards, you may get 1 in return on most acquisitions, and 5 again on expenditures made using convenience stores, gasoline stations, grocery stores and also ‘member merchants’.
I can’t believe how amazing this article is! The author has done a fantastic job of delivering the information in an captivating and informative manner. I can’t thank him enough for providing such valuable insights that have certainly enhanced my knowledge in this subject area. Hats off to her for crafting such a work of art!
Thank you, I have been looking for information about this topic for ages and yours is the best I have found so far.