Goyal, M. M., & Basak, A. (2012, November). Hydroxyl Radical Generation Theory: A Possible Explanation of Unexplained Actions of Mammalian Catalase. International Journal of Biochemistry and Molecular Biology, 3(3), 282-289. doi:10.1016/j.freeradbiomed.2012.10.050
This paper starts out describing the accepted mechanism of normal mammalian catalase mechanism: the conversion of two molecules of hydrogen peroxide into two molecules of water through an oxyferryl intermediate. What makes this paper stand out is that it is the first paper (to our knowledge) that has mechanistically outlined how ethanol is oxidized to acetaldehyde in catalase. From the mechanism proposed on page 283 and the scheme on page 286, we were able to determine the arrow-pushing sequence for the oxidation of ethanol based on their hydroxyl radical generation theory.
To learn more about catalase and its mechanism based on this paper, click here